ID A0A3Q7SNL0_VULVU Unreviewed; 2894 AA.
AC A0A3Q7SNL0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=A-kinase anchor protein 13 isoform X3 {ECO:0000313|RefSeq:XP_025857151.1};
GN Name=AKAP13 {ECO:0000313|RefSeq:XP_025857151.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025857151.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025857151.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025857151.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025857151.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_025857151.1; XM_026001366.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20878; C1_AKAP13; 1.
DR CDD; cd13392; PH_AKAP13; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944:SF18; A-KINASE ANCHOR PROTEIN 13; 1.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1795..1842
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1997..2194
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 2234..2336
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 302..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1456..1485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1501..1528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1547..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1757..1787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2470..2509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2703..2808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2350..2381
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2574..2685
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 302..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1763..1787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2482..2505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2720..2736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2748..2773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2894 AA; 314786 MW; 5AFB5AA09D4AE4B3 CRC64;
MKLNPQQAPL YGDCVVTVLL AEEDKVEDDV VFYLVFSGST LYHCTSTRKV SADTLETIAP
GHDCCETVKV LLCASKEGLP VFVVAEEDFQ FIQDEAYDAA QFLATSAGNQ QALNFTRFLD
RSGPPSGDVN SLDEKVALAF RHLKLPAEWN VLGTDQTLHD GSPRETLMHF AVRLGLLRLT
WFLLQKPGGR GALSIHNQEG ATPVSLALER GYHKLHQLLT QENAEEPDSW SSLSYEIPYG
DCSVRHHREL DVYTLTSESK SHHEPSVPGN SCTGHIFKLM NIQQQLMKTN LKQMDNPIPL
MVTAQDPSSV PSAQDSDGQF LCCTSDPRDS QPHSYLPEDP ESSPCGQGST VGEIEGSSDF
SCVAKEENTD CSCKKETKGV EKEGEEAEPS LTVDCGTMSD LSSRSLSMPA CGGKGMGTLP
PCGIRNGETG TKSSALATDQ ESLDTGDSVL QGDGGMQPAT APTQHFSGCE LAAGIPVTPG
EMESGPVNAH AAIQKNVLEV RESTKEKLEN SNIITDGSSD VKVTNQTADK ASVPNCVSAT
SSPDGDKPAE SLLAFSNGEA SPVKTAETET SRSYEGSAGA PMDQSSLVIP AAAEDTTSDG
LELYAPLTGT SEAASPSDLT FPRPQKDAPN HKSEPESSHI QSQTSRSPIC STTRGDTPCA
AFACGQSSVT SSGMLAAEYC DGIVTQPEST TPGLPPTQHP PLALCCEGSQ ANAATPGPMR
DTLEQVEFCP VEVSDKKGQG EDLKLGTSST NMLEVHPQAV VPKAKKELVP DQAVTSDKTF
SLASSPGSES VTKDDALFLF PSQKEKGIAT PELHTAADGR DGPGRDSNDP DKQPLEDGAT
GLSTPSLAVQ LQPSMGNTSP MGLGGEHGSV CLSAAPEVLD IEGAVDSSVL CAGKAAVASD
SILTEEGKNL VVPESSEAQG QDGRDKAAAC SFLKEDTHSS GTFQEEQRTP PPGQEALGFC
GEPGSAACAE DRARKRGNSL GTPSACLNAE TEHNKEVAPP VSLLTEGGAA QSLVPLGASL
AADPSQEALG AQKSSSALLP DLLPDLLPDL LPDLLPDGSE ALSRNGSFAL DVGVQNPESQ
GKNTAHEVSG NVQLDVAVVN ALQGNAGARR KAISHNARDL PIPEVLSQEK NMFLGFPGAL
ADEGVTDLQG AAAPEMVPLR GKERDNNCGL ANSGKAQVDP KAHHILEQPL AKELPTETGL
SSSGDQALGR ARGTLLLPCA VPLPKGADSI EEAACRIVEA VLDQVRFSGA LITGQEISHM
SLSRPSESDP VTEQPEGAST GQVSTFLPVQ TVHMGSICEE APGTFAGYLA ETEEPEKMVL
PAEGSEPATE MPDLKAADEV DFLSNTGVSS ASTEVAVKDA ATPPDMKQGL MTQAINRESW
CTIKPCPDAT SLLAAAQSPE CENFLDVGLS RECASKQAVL KRESGSDSDL FHSPSEEVDS
IIFPKPEEEQ LVCDITGSSS STDDTASLDR HSSHGSDVSL PQISNLNRSR DQQCLDSFYS
HGVGAEGRES EGEAAGSGEM EEEEMDSITE VPANCSVLRS SMRSLSPFRR HSWGPGKNAA
SDAEMNQRSS LQVLGDVVRR PPIHRRSMSW CPSGVQYSAA LSADFNYRSF SLEGLTGGAG
AGNKPSSSLD VNSINTKELR HPFNGEERGD SLVSLSEEDL ESGQREHRML DQQACHRSKQ
QGFNYCTSAI SSPLTKSISL MTISHPGLDH SRPFHSTSAN LTESITEETY SFLPQSPSKK
DFEGKSGTKV SRTFSYIKNK MSSSKKSRQE KEKEKEKIKE KEKDLKEKDK KTINGHTFSP
IPVVGPISCS QCVKPFTSKD AYTCAGCSAF VHKGCRESLA SCAKVKMKQP RGSLQAQDTS
SLPTVIMRSK PSQPKERPRS AVLLADEATA IPMFANRRSQ QSISLSKSVS IQNIAGVGND
ENISNTWKFL SHSTDSLNKI SKVNESTESL TDEVGTDMNE GQLMGDFEME SKQLEAESWS
RVVDSKFLKQ QKKDVVKRQE VIYELMQTEL HHIRTLKIMS DVYSRGMMTE LLFEQQTVEK
LFPCLDELIS IHSQFFQRIL ERKKESLVDK SEKNFLIKRM GDVLVNQFSG ENAERLKKTY
GKFCGQHNQS VNYFKDLHTK DKRFQAFVKK KMSSAVVRRL GIPECILLVT QRITKYPVLF
QRILQCTKDN EVEQEDLAQS LSLVKDVIGA VDSKVASYEK KVRLNEIYTK TDSKSIMRMK
SGQMFAKEDL KRKKLVRDGG VFLKNAAGRL KEVQAVLLTD ILVFLQEKDQ KYVFASLDQK
STVISLKKLI VREVAHEEKG LFLISMGMKD PEMVEVHASS KEERNSWIQI IQDTINTLNR
DEDEGIPSEN EEEKRILDTK ARELKEQLQQ KDQQILLLLE EKEMIFRDMT ECSTPLPEDC
SPTHSSRILF RSNTEEALKG GPLMKSAINE VEILQGLVSG SLGGTLGPAV SSPVEQEGIV
GPVSLPRRAE TFGGFDSHQM NASKGGEKEE GEDGQDLRRT ESDSGLKKGG NANLVFMLKR
NSEQLVQSVI HLHELLSTLQ GVVLQQDSYI EDQKLLLAER ALTRSSSRPS SLVEQEKQRS
LEKQRQDLAN LQKQQAQHLE EKRRREREWE ARERALQERE ARLAQREQDV WRGQQDLDRE
REELQHKKGA YQCDLERLRA AQKQLEREQE QLKRDAERLS QRQVEHDACQ VSYQHTKLLR
IPSFFPNPEE PPMPSVPSIA KSGSLDSELS VSPKRNSISR THKDKGPFHI LSSTSQTNKV
PEGQSQTPVP ASASTRLFGL AKPKEKKEKK KKNKGSRSQP CGELPTPGPL QPHCPQILKG
GQVSVAWGWL NWGHSGVCCL ARRTCFACEG CWDSHLEYQL CGHLRHPPPL CTRVPRRVCR
SHIPGICFPT EAPR
//
