ID A0A3Q7SPP4_VULVU Unreviewed; 3312 AA.
AC A0A3Q7SPP4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Lysosomal-trafficking regulator isoform X3 {ECO:0000313|RefSeq:XP_025864509.1};
GN Name=LYST {ECO:0000313|RefSeq:XP_025864509.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025864509.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025864509.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025864509.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025864509.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025864509.1; XM_026008724.1.
DR Proteomes; UP000286640; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 3009..3115
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3120..3312
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 142..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3312 AA; 375314 MW; BAC873294A900EB5 CRC64;
MSIDSNSLAR EFLTDVNRLC NAVVQRVEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFNLPF SADIILTKEK NSSSQRSTQE
KLYLEGSAPS GQVSAKVNIF QKSRRQRKST HRYSIRDARK TRLSTSDSEA NSDDKSVAMS
KHRRPRLLQH FVTQSPKEDH LTAKLDRLPT KEETPPDTMA LENPKEVIPR LESNTDILSE
PAALSIISHM NNSPFDLCHV LLSLLEKVCK FDITLNHNSA LAATVVPTLT EFLAGFGDCC
NLSDNLESQM VSTGWTEEPV ALIQRMLFRT VLHLMSVDIS TEEMMPENLR KNLTELLRAA
LKIRTCLEKQ PDPFAPRQKR TLQEVREGFV FSKYRHRALL LPELLEGVLQ ILICCLQSAA
SNPFSFSQAM DLVQEFIQHH GFNLFETAVL QMEWLVVRDG VPTEASEHLK ALISSVLKIM
STVKKVKSEQ LHHSMCTRKR HRRCEYSHFM HHHRDLSGLL VSAFKNQVSK NPFEETADGD
VYYPERCCCI AVCAHQCLRL LRQASLSSTC VQILSGVHNV GICCCMDPKS VIIPLLHAFK
LPVLKHFQQQ ILSILNKLIL DQLGGAEKPQ KIKQAACNIC TIDPDQLAKL EETLQGNSCA
AEPSPNLSSL SYRFHGILPS SGSEDLLWKW DALEAYQNFV FEEDRLHSIQ IANHICNLIQ
KGNVVVQWKL YNYVFNPVLQ RGVELAHHCQ HLSITSAQTH VCSYHNQCLP QEVLQIYLKT
LPTLLKSRVI RDLFLSCNGV NQIIELNYLD GIRSHSLKAF ETLIISLGEQ QKDSSVPGID
GIDVEQKELS SLNVGTSFRN QQAYPDSPQS LSKFYASLKE AYPKKRKSVN QDVHINMINL
FLCVAFLCVS KEAESDRESA NDSEDTSGYD STASEPLHHM PPCLSPESLV LPSPKHMHHA
ADIWSMCRWI YMLSPVFQKQ FYRLGGFQAC HKLIFMIIQK VFRSHEEEQG KREGDLNVHE
NQDIKRTSQP EITMKDDLLS LTIKRDPTPS ELGSLNKSPD SLGKLESQHI SSINVRHISA
TEAAPEETKV FTSRENETSL QSIRLLEALL AICLHSTRAS QQKMELELPN QNFTVENILF
EMRDHLSQSK VIETELAKPL FDALLRVALG DHSADFEHHD AMTEKSHHSE EELSPQPGDF
SEEAEDSQCY SLKLLLEEEG YEADGESNPE DSETRDDGVD IKPEAESFSA SSSPKDWLEN
LTDGEIIYPE ICMLELSLLS TGKARLDVLA HVFESFLKII RQKEKNIFLL MQQGTVKNLL
GGFLSILTQA DSDFQACQRV LVDLLVSLMS SRTCSEELTL LLRIFLEKSP CTEVLLVGIL
KIIESDIIMS PSQYLTFPLL HTPNLSNGVS SQKCPGILNS KALGLLRRAR SSRSRKEADN
GSLPQQLLSS WHIAPIHLPL LGQNCWPHLS EGFSVSLWFN MECIQEAESI MEKGKKIKKR
NKSLVLQDSS LDRTENNRPE CAEYTNPGER LIEEGCIHMI SLGSKALMIQ VWADPHNGTF
IFRMCMDSND DMKAVLLAQV ESQENIFVPS KWQHLVLTYL QQSQGKKNNH GKISIWISGQ
RKPDVSLDFV LPRRTSLSSD SNKTFCMIGH CLSSQEEFLQ LAGKWDLGNL LLFNGAKIDS
QEAFYLYACG PNHTSIMPCR YGKPVNDYSK YINKEILQCE QIRELFMTKK EVDIGLLIES
LSVVYTTNCP AQYTIYEPVI RLKGQMKTQL SQRPFSSKEV QSILLEPHHL KNLRPTECKT
IQGILHEIGG TGIFVFLFAR VVELSSREET QALALRVILS LTKYNQQRIH ELENCNGLSM
IHQVLIKQKC IVGFHVLKTL LEGCCDEDII HVNENGEFKL DVESNAIIQD VKLLEELLLD
WKIWNKAKQG AWETLLAALE VLIRADHHQQ VFNIKQLLKA RVVHHFLLTC QVLQEHKEGQ
LTSMPREVCN SFVKIIAEVL GSPPDLELLT IIFNFLLAVH PPTNTYVCHN PTNFYFSLHI
DGKIFQEKVQ SIMYLRHSSS GGKSVPSPGF MVISPSGFTA SPPEGNNSSN IIPQRMTINM
LRSRSLPAFP TASPRVQPQK LTGSLGCSID KLQNIADNYA ASQAEKLNSL ASSETLKKGK
EDALVSSFDS AKAVCEMEAA LSARTSVNGV PKGTLGFLGV KGYHKELAAE LRSDDDSPGD
ESCPRRPDYL KGLASFQRSH STIASLGLAF PSQNGSAAVG RWPSLVDRNT DDWENFAFSL
GYEPYSSRTA STHSVTEDCL VPICCGLYEL LSGILLILPD VMLQDVMDKL IQADTLLVLV
NHPSPAIQQG VIKLLDAYFN RASKEQKDKF LKNRGFSLLA NQLYLHRGTQ ELLECFIEMF
FGRRIGLDEE FDLEDVKNMG LFQKWSVIPL LGLIETSLYD NMLLHSSLLL LLQILNSCSK
VADMLLDNGL LYVLCNTVAA LNGLEKNVPL NEYKLLACDI QQIFVAVTIH ACSSSGSQYF
RVIEDLIVLL GYLQNSKNKR TQNMAVALQF RVLQAAMEFI RTTANHDSEN LADTFQLPSA
PHHAVFQKRK SVAGPRKFPL AQTDSLLMKM RSVASDELHV MMQRRMSQEN PVQATETELA
QRLQRLTILA VNRIIYQEFN PDIIDILSTP ENATQSKISV SQTEISEENV HHEQPSIFHP
FQKEILTYLI EGFKASIGSS KTSGSKQQWT KIVWSCKETF RMQLGRLLVH ILSPAHSSQE
RKQIFEIVHE PNHQEILRDC LSPSLQHGAK LVLYLSELIH NHQDELTEEE LDTAELLMNA
LKLCGQKCIP PTATTKADLI KMIKEEQKKY ETEEGTNKAT WQRTVNNNQQ SLFQRLDSKS
KDISKIAADI TQAVSLSQGI ERKKVIQYIR GMYKVDLSAS RHWQELIQQL THDRAAWYDP
LYYPTSWQLD PTEGPNRERR RLQRCYLTIP NKYLLRDRQK SEDVVKPPLS FLFEDKTHSS
FSSTVKDKAA SESIRVNRRC ISVAPSRETA GELLLGKCGM YFVEDNASDT VESSSLQGEL
EPASFSWTYE EIKEVHKRWW QLRDNAVEIF LTNGRTLLLA FDNTKVRDDV YHSILTNNLP
NLLEYGNINA LTNLWYTGQI TNFEYLTHLN KHAGRSFNDL MQYPVFPFIL ADYVSETLDL
SDPSVYRNLS KPIAVQYKEK EDRYVDTYKY LEEEYRKGAR EDDPMPPVQP YHYGSHYSNS
GTVLHFLVRM PPFTKMFLAY QDQSFDIPDR TFHSTNTTWR LSSFESMTDV KELIPEFFYL
PEFLVNREGS RV
//
