ID A0A3Q7SQ57_VULVU Unreviewed; 576 AA.
AC A0A3Q7SQ57;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=SH2 domain-containing protein 3A isoform X1 {ECO:0000313|RefSeq:XP_025844280.1};
GN Name=SH2D3A {ECO:0000313|RefSeq:XP_025844280.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025844280.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025844280.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025844280.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025844280.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025844280.1; XM_025988495.1.
DR AlphaFoldDB; A0A3Q7SQ57; -.
DR STRING; 9627.ENSVVUP00000027962; -.
DR Ensembl; ENSVVUT00000037127; ENSVVUP00000027962; ENSVVUG00000020490.
DR KEGG; vvp:112911827; -.
DR OMA; WWEANEE; -.
DR OrthoDB; 2953960at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF11; SH2 DOMAIN-CONTAINING PROTEIN 3A; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 15..114
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 313..575
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 136..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 62613 MW; AD0FDC1973CEEDE5 CRC64;
MQVPQDGEDF ASQPWYHGPI SRQKAEALLQ QDGDFLVRAS RSRGGHPVIS CRWQGSALHF
EVLRVALRPR PGRPTALFQL EDERFPSLPS LVLSYVTGQR PLSQATGAVA SRPVIRQGPI
RRSFSEDTLL ESPARIELPR ARKRSDSQPA GLEHMGLSGE DHSGPGASPV PTCALPRMGS
DPVLLKTPAS LGSVVDGLRA SDGQLHAKAP NKPPRTPSLV LHDASGRPPT YCELVPRVPS
AQETPTGHSG PETEASWWEA NEEEEEEDRS FARPKAEVFF CPPNNLFCLL GPQNRPLEPK
VLSTLRDLFL EHHPGSTALH LLLVDCQATG LLGVTKAQRG AMGVTSGLEL LTLPHGHRLR
LELLERHEAL ALAGALAVLG CSGPLEERAA TLRGLVELAL ALRPGAAGDL PGLAAVMGAL
LMPQVSRLER TWRQLRRSHT QAALAFEQEL KPLMRALDEG AGPCAPGEVA LPHVVPAVRL
LEGQELPGPL DESCERLLRT LHRARLVARD APQFREAAAR RLRGFQPNPQ LREALTTGFV
QRLLWGSQGV GAPHATRLEK FQRVLSALSQ RLEPDV
//
