ID A0A3Q7SQG7_VULVU Unreviewed; 919 AA.
AC A0A3Q7SQG7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3 {ECO:0000313|RefSeq:XP_025864924.1};
GN Name=ASAP2 {ECO:0000313|RefSeq:XP_025864924.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025864924.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025864924.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025864924.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025864924.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025864924.1; XM_026009139.1.
DR AlphaFoldDB; A0A3Q7SQG7; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08849; ArfGap_ASAP2; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR CDD; cd11966; SH3_ASAP2; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR035677; ASAP2_SH3.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF4; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 260..352
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 376..498
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 575..607
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 857..919
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 235..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..763
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..802
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 102246 MW; 5C4155017EBCE651 CRC64;
MVLYKMKKSV KAINISGLAH VENEEQYTQA LEKFGGNCVC RDDPDLGSAF LKFSVFTKEL
TALFKNLIQN MNNIISFPLD SLLKGDLKGV KGDLKKPFDK AWKDYETKIT KIEKEKKEHA
KLHGMIRTEI SGAEIAEEME KERRLFQLQM CEYLLKVNEI KIKKGVDLLQ NLIKYFHAQC
NFFQDGLKAV ESLKPSIETL STDLHTIKQA QDEERRQLIQ LRDILKSALQ VEQKESRRDS
QIRQSTAYSL HQPQGNKEHG TERNGNLYKK SDGIRKVWQK RKCSVKNGFL TISHGTANRP
PAKLNLLTCQ VKTNPEEKKC FDLISHDRTY HFQAEDEQEC QIWMSVLQNS KEEALNNAFK
GDDNTGENNI VQELTKEIIS EVQKMTGNDV CCDCGAPDPT WLSTNLGILT CIECSGIHRE
LGVHYSRMQS LTLDVLGTSE LLLAKNIGNA GFNEIMEYCL PAEDSVKPNP GSDMNARKDY
ITAKYIERKY ARKRHADNAA KLHSLCEAVK TRDIFGLLQA YADGVDLTEK IPLANGHEPD
ETALHLAVRS VDRTSLHIVD FLVQNSGNLD KQTGKGSTAL HYCCLTDNAE CLKLLLRGKA
SIETANESGE TPLDIAKRLR HEHCEELLTQ ALSGRFNSHV HVEYEWRLLH EDLDESDDDV
DEKLQPSPSR REDRPVSFYQ LGSNQLQSNA ASLARDAASL AKDKQRSFVP SILQNETYGA
ILSGSPPPTQ PAAPSTASAP PLPPRNVAKD PLAPTPPPPV AKTPSVIEAL SQQSKPAQPG
ISLSKAPPPP LPPQPPSRLP QKRPAPGADK STPLINKGQP RGPAADLSGT EVLGPLSNTG
VLQPPAPMPR KSQTTKLKPK RVKALYNCVA DNPDELTFSE GDVIIVDGEE DQEWWIGHID
GDPSRKGAFP VSFVHFIAD
//
