ID A0A3Q7SQJ5_VULVU Unreviewed; 1186 AA.
AC A0A3Q7SQJ5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Myelin transcription factor 1-like protein isoform X5 {ECO:0000313|RefSeq:XP_025864969.1};
GN Name=MYT1L {ECO:0000313|RefSeq:XP_025864969.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025864969.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025864969.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025864969.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025864969.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MYT1 family.
CC {ECO:0000256|ARBA:ARBA00010194}.
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DR RefSeq; XP_025864969.1; XM_026009184.1.
DR AlphaFoldDB; A0A3Q7SQJ5; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.320.30; -; 6.
DR InterPro; IPR013681; Myelin_TF.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR10816:SF11; MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN; 1.
DR PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR Pfam; PF08474; MYT1; 1.
DR Pfam; PF01530; zf-C2HC; 6.
DR SUPFAM; SSF103637; CCHHC domain; 6.
DR PROSITE; PS51802; ZF_CCHHC; 6.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT DOMAIN 622..872
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1058..1127
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..170
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1186 AA; 132675 MW; 9EB77812D514EC76 CRC64;
MEVDAEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR SVYGCPLAKK
RKTQDKQPQE PAPKRKPFAV KADSSSVDEC YESEGSEDVD EKEEDEEEEF SEDEDEHREE
DEEDEEGDRE EEEELEEEED DDDEDGEDVE DEEEDEEEED DDDEEEEDNE DHQMSCHNSR
IMQDAEKDDN NNEEYDNYDE LVAKSLLNLG KIAEDAAYRA RTESEMNSNT STSLEDGSDR
NEALGRKSEL SLDLDSDVVR ETVDSLKLLA QGHGVVLAEN LNDRAYADSL SQQDSRNMNY
VMLGKPMNNG LMDKMVEESD EEVCLSSLEC LRNQCFDLAR KLSETNPQDR SQQQNMNIRQ
HVRQEDDFAG RTPDRNYSDM MNLMRLEEQL SPRSRTFSSC AKEDGYHERD DDTTSVNSDR
SEEVFDMTKG NLTLLEKAIA LETERAKAMR DKMAMEAGRR DNVRSYEEQS PRQLPGEERK
PKSSDSHVKK PYYGKDPSRA EKKESKCPTP GCDGTGHVTG LYPHHRSLSG CPHKDRVPPE
ILAMHENVLK CPTPGCTGRG HVNSNRNSHR SLSGCPIAAA EKLAKAQEKH QSCDVSKSNQ
ASDRVLRPMC FVKQLEIPHY GYRNNVPTTT PRSNLAKELE KYSKTSFEYN TYDSHTYGKR
AIAPKVQTRD ISPKGYDAKR YCKNASPSSS TTSSYAPSSS SNMSCGGGSS ASSTCSKSSF
DYAHDMEAAH MAATAILNLS TRCREMPQNL STKPQDLCAA RNPDMEVDEN GTLDLSMNKP
RPRESCCPVL TPLEPMSPQQ QAVMGSRCFQ LGEDDCWELP VDYTKMKPRR ADGGDASEVP
PEDLDPFQEA LEERRYPGEV TIPSPKPKYP QCKESKKDLI TLSGCPLADK SIRSMLATSS
QELKCPTPGC DGSGHITGNY ASHRSLSGCP RAKKSGIRIA QSKEDKEDQE PIRCPVPGCD
GQGHITGKYA SHRSASGCPL AAKRQKDGYL NGSQFSWKSV KTEGMSCPTP GCDGSGHVSG
SFLTHRSLSG CPRATSAMKK AKLSGEQMLT IRQRASNGIE NDEEIKQLDE EIKELNESNS
QMEADMIKLR TQITTMESSL KTIEEENKVI EQQNESLLHE LANLSQSLIH SLANIQLPHM
DPINEQNFDA YVTTLTDMYT NQDRYQSPEN KALLENIKHA VRGIQV
//
