ID A0A3Q7SR81_VULVU Unreviewed; 1096 AA.
AC A0A3Q7SR81;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 isoform X5 {ECO:0000313|RefSeq:XP_025865334.1};
GN Name=RAPGEF1 {ECO:0000313|RefSeq:XP_025865334.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025865334.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025865334.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025865334.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025865334.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025865334.1; XM_026009549.1.
DR AlphaFoldDB; A0A3Q7SR81; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 707..829
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 859..1083
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..309
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..461
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1096 AA; 123159 MW; F0968AF46BCB0C44 CRC64;
MGNAAEKQKP RKPSRLCPWK QDSQRSHLSS FTMKLKDKFH SPKIKRTPSK KGKPAEVSVK
NPEKPVSKEA TDRFLPEGYP LPLDLEQQAV EFMSTSAVAS RSQRQKNLSW LEEKEKEVVS
ALRYFKTIVD KMAIDKKVLE MLPGSASKVL EAILPLVQSD PRIQHSSALS SCYSRVYQSL
ANLIRWSDQV MLEGVNSEDK ETVTTVKGVI KAVLDGVKEL VRLTIEKQGH PSPTSPVKPS
SPACKPDGQS ELPLTDREVE ILNKTTGMSQ SAELLPDSTD EEIAPPKPPL PGIRVVDNSP
PPALPPKKRQ SAPSPTRVAV VAPMSRATSG SSLPVGINRQ DFDVDCYTQR RLSGGSHSYG
GESPRLSPCS SIGKLSKSDE QLSSLDRDSG QCSRNTSCET LDHYDPDYEF LQQDLSNADQ
IPQQVACNLS PLPESLGESG SPFLGHPFQL PPAPGSCPQP EGPLAPGQQI DMPPALPEKK
RRSAASQTTD SSGCRMSYER HPSQYDNISE DDLQNPASVP SVPFTPFAAI LPFQQGGSSA
SVEFVGDFTV PESTTGDPEK PPPLPEKKNK HMLAYMQLLE DYSEPQPSMF YQTPQNEHIY
QQKNKLLMEV YGFNDSFSTE APQELAPPPA LPPKQRQLES PAMKDGHPRD PSSVSSTPGK
ESRDSDRASR SPDGSELARL EEEVDELSLI DHNEIMARLT LKQEGDDGPD VRGGSGDILL
VHATETDRKD LVLYCEAFLT TYRTFITPEE LIKKLQYRYE KFSPFADTFK KRVSKNTFFV
LVRVVDELCL VELTEEILKL LMELVFRLVC NGELSLARVL RKNILDKVDQ KKLLRCANSD
QPLAARGVAA RPGTLHDFHS HEIAEQLTLL DAELFYKIEI PEVLLWAKEQ NEEKSPNLTQ
FTEHFNNMSY WVRSIIMLQE KAQDRERLLL KFIKIMKHLR KLNNFNSYLA ILSALDSAPI
RRLEWQKQTS EGLAEYCTLI DSSSSFRAYR AALSEVEPPC IPYLGLILQD LTFVHLGNPD
YIDGKVNFSK RWQQFNILDS MRCFQQAHYD IRRNDDIINF FNDFSDHLAE EALWELSLKI
KPRNITRRKT DREEKT
//
