ID A0A3Q7ST79_VULVU Unreviewed; 700 AA.
AC A0A3Q7ST79;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase {ECO:0000256|PIRNR:PIRNR002006};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR002006};
GN Name=PTPRE {ECO:0000313|RefSeq:XP_025866454.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025866454.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025866454.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025866454.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025866454.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR002006};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00007765,
CC ECO:0000256|PIRNR:PIRNR002006}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025866454.1; XM_026010669.1.
DR AlphaFoldDB; A0A3Q7ST79; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14620; R-PTPc-E-1; 1.
DR CDD; cd14622; R-PTPc-E-2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR016336; Tyr_Pase_rcpt_a/e-type.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF499; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PIRSF; PIRSF002006; PTPR_alpha_epsilon; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR002006};
KW Membrane {ECO:0000256|PIRNR:PIRNR002006};
KW Phosphoprotein {ECO:0000256|PIRSR:PIRSR002006-3};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR002006};
KW Receptor {ECO:0000313|RefSeq:XP_025866454.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Signal {ECO:0000256|PIRNR:PIRNR002006};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR002006};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR002006}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT CHAIN 20..700
FT /note="Receptor-type tyrosine-protein phosphatase"
FT /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT /id="PRO_5018383589"
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT DOMAIN 136..394
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 314..385
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 426..689
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 605..680
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT ACT_SITE 335
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT ACT_SITE 630
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT BINDING 303
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 335..341
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 379
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT MOD_RES 696
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-3"
SQ SEQUENCE 700 AA; 80477 MW; E06E7CBA878DCBCD CRC64;
MEPICPLLLA GVSLPLARAL KGNETTPAYS NWTSTTSGPP DPGAPQPQLA WLLLPLLLCV
LLLLLAAYFF RFRKQRKAVV SANDKKMPNG ILEEQEQQRV MLLSRSPSGP KKYFPIPVAH
LEEEIRVRSA DDCKRFREEF NSLPSGHIQG TFELANKEEN REKNRYPNIL PNDHSRVILS
QVDGTPCSDY INASYIDGYK EKNKFIAAQG PKQETVNDFW RMIWEQKSAT IVMLTNVKER
KEEKCYQYWP DQGCWTYGNI RVCVEDCVVL VDYTIRKFCI QSLPDGCKAP RLVSQLHFTS
WPDFGVPFTP IGMLKFLKKV KALNPAHAGP IVVHCSAGVG RTGTFIVIDA MMDMMHAEQK
VDVFEFVSRI RNQRPQMVQT DMQYTFIYQA LLEYYLYGDT ELDVSSLEKH LQTLHGTTSH
FDKIGLEEEF RKLTNVRIMK ENMRTGNLPA NMKKARVIQI IPYDFNRVIL SMKRGQEYTD
YINASFIDGY RQKDYFIATQ GPLAHTVEDF WRMVWEWKCH TVVMLTEVQE REQDKCYQYW
PTEGSVTHGD ITIEIKSDTL SEAISIRDFL VTFNQPLARQ EEQTRVVRQF HFHGWPEIGI
PAEGKGMIDL IAAVQKQQQQ TGNHPITVHC SAGAGRTGTF IALSNILERV KAEGLLDVFQ
AVKSLRLQRP HMVQTLEQYE FCYKVVQDFI DIFSDYANFK
//