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Database: UniProt
Entry: A0A3Q7ST79_VULVU
LinkDB: A0A3Q7ST79_VULVU
Original site: A0A3Q7ST79_VULVU 
ID   A0A3Q7ST79_VULVU        Unreviewed;       700 AA.
AC   A0A3Q7ST79;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Receptor-type tyrosine-protein phosphatase {ECO:0000256|PIRNR:PIRNR002006};
DE            EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR002006};
GN   Name=PTPRE {ECO:0000313|RefSeq:XP_025866454.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025866454.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025866454.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025866454.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025866454.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|PIRNR:PIRNR002006};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00007765,
CC       ECO:0000256|PIRNR:PIRNR002006}.
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DR   RefSeq; XP_025866454.1; XM_026010669.1.
DR   AlphaFoldDB; A0A3Q7ST79; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd14620; R-PTPc-E-1; 1.
DR   CDD; cd14622; R-PTPc-E-2; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR016336; Tyr_Pase_rcpt_a/e-type.
DR   PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR19134:SF499; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON; 1.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PIRSF; PIRSF002006; PTPR_alpha_epsilon; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR002006};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002006};
KW   Phosphoprotein {ECO:0000256|PIRSR:PIRSR002006-3};
KW   Protein phosphatase {ECO:0000256|PIRNR:PIRNR002006};
KW   Receptor {ECO:0000313|RefSeq:XP_025866454.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Signal {ECO:0000256|PIRNR:PIRNR002006};
KW   Transmembrane {ECO:0000256|PIRNR:PIRNR002006};
KW   Transmembrane helix {ECO:0000256|PIRNR:PIRNR002006}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT   CHAIN           20..700
FT                   /note="Receptor-type tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT                   /id="PRO_5018383589"
FT   TRANSMEM        49..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT   DOMAIN          136..394
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          314..385
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   DOMAIN          426..689
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          605..680
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   ACT_SITE        335
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT   ACT_SITE        630
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT   BINDING         303
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT   BINDING         335..341
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT   BINDING         379
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT   MOD_RES         696
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002006-3"
SQ   SEQUENCE   700 AA;  80477 MW;  E06E7CBA878DCBCD CRC64;
     MEPICPLLLA GVSLPLARAL KGNETTPAYS NWTSTTSGPP DPGAPQPQLA WLLLPLLLCV
     LLLLLAAYFF RFRKQRKAVV SANDKKMPNG ILEEQEQQRV MLLSRSPSGP KKYFPIPVAH
     LEEEIRVRSA DDCKRFREEF NSLPSGHIQG TFELANKEEN REKNRYPNIL PNDHSRVILS
     QVDGTPCSDY INASYIDGYK EKNKFIAAQG PKQETVNDFW RMIWEQKSAT IVMLTNVKER
     KEEKCYQYWP DQGCWTYGNI RVCVEDCVVL VDYTIRKFCI QSLPDGCKAP RLVSQLHFTS
     WPDFGVPFTP IGMLKFLKKV KALNPAHAGP IVVHCSAGVG RTGTFIVIDA MMDMMHAEQK
     VDVFEFVSRI RNQRPQMVQT DMQYTFIYQA LLEYYLYGDT ELDVSSLEKH LQTLHGTTSH
     FDKIGLEEEF RKLTNVRIMK ENMRTGNLPA NMKKARVIQI IPYDFNRVIL SMKRGQEYTD
     YINASFIDGY RQKDYFIATQ GPLAHTVEDF WRMVWEWKCH TVVMLTEVQE REQDKCYQYW
     PTEGSVTHGD ITIEIKSDTL SEAISIRDFL VTFNQPLARQ EEQTRVVRQF HFHGWPEIGI
     PAEGKGMIDL IAAVQKQQQQ TGNHPITVHC SAGAGRTGTF IALSNILERV KAEGLLDVFQ
     AVKSLRLQRP HMVQTLEQYE FCYKVVQDFI DIFSDYANFK
//
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