ID A0A3Q7STB1_VULVU Unreviewed; 387 AA.
AC A0A3Q7STB1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=G-protein coupled receptor family C group 5 member B {ECO:0000313|RefSeq:XP_025858991.1};
GN Name=GPRC5B {ECO:0000313|RefSeq:XP_025858991.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025858991.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025858991.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025858991.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025858991.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_025858991.1; XM_026003206.1.
DR AlphaFoldDB; A0A3Q7STB1; -.
DR STRING; 9627.ENSVVUP00000031831; -.
DR Ensembl; ENSVVUT00000042244; ENSVVUP00000031831; ENSVVUG00000023141.
DR KEGG; vvp:112923373; -.
DR OMA; QRRDKWS; -.
DR OrthoDB; 4263681at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
DR CDD; cd15278; 7tmC_RAIG2_GPRC5B; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR PANTHER; PTHR14511; G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5; 1.
DR PANTHER; PTHR14511:SF9; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER B; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_025858991.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..387
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018787653"
FT TRANSMEM 46..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..247
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 387 AA; 43096 MW; ED97D54A868EB2BB CRC64;
MRTHKVLAFL LLFVIAFGAS ENASTSRGCG LDLLPQYVSL CDLDTIWGIV VEAVAGAGAL
ITLLLMLILL VRLPFIKDKE KKDPVGLHFL FLLGTLGLFG LTFAFIIRED ETICSVRRFL
WGVLFALCFS CLLSQAWRVR RLVRHGKSPS GWQLVGVALC LMLVQVIIAI EWLVLTVLRD
AKPACAYEPM DFVMALIYDM VLLVATLGLA LFTLCGKFKK WKQNGACILV TAFLSVLIWV
AWMTMYLFGN AELRQGDAWG DPTLAITLVA SGWVFVIFHA IPEIHCTILP APQENTPNYF
DTSQPRMRET AFEEDVQLPR TYMENKAFSM DEHNAALRTA GFRNGSLGNR PSAPFRSNVY
QPTEMAVVLN GGTIPTAPPS YTGRHLW
//
