ID A0A3Q7STB7_VULVU Unreviewed; 3186 AA.
AC A0A3Q7STB7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=WD repeat- and FYVE domain-containing protein 4 {ECO:0000313|RefSeq:XP_025845510.1};
GN Name=WDFY4 {ECO:0000313|RefSeq:XP_025845510.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025845510.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025845510.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025845510.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025845510.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025845510.1; XM_025989725.1.
DR STRING; 9627.ENSVVUP00000028685; -.
DR KEGG; vvp:112913132; -.
DR OrthoDB; 47483at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF3; WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2388..2513
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2530..2824
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2981..3022
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3090..3112
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1835..1856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2324..2346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1837..1852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3186 AA; 355792 MW; 4588C08EE90AE680 CRC64;
MEAEGVSRAE DRAEYPGSKN EGQPDVAQPD FPHGEQSPGP TALWEMLERK FLEYQQLAHG
SPAEHQQSLL NLLPLFLKAW ENSVGIISFP SLQRLARDTS NQLAQEIQKA LVGKPAEQAR
EAAWQLLRWK GKVDQDGYLL LKSVFVLTGT NSETLGQVAE SGLPALLLQC LYLFFVFPLE
KDELFESDVQ IQRMFVQMLL NICNESQGLE RLLSGNELQS LVIATTCLRE HSCCFWKEPT
FCVLRAISKA QNLGIIQYLQ VMDCIKLSVQ NLSKLAESLP TPEVSEAVNL ILGFVKDSYP
VSSALFLEFE NGEGYPLILK VLLRYDGLTQ SEVDPHLEEL LELLVWLTTC GRSELKVFDS
VMYPQLEGFK FHHEASGVTV KNLQAFQVLQ NVFHKASSPA LCTKVLSAIR TMWSWNARNF
FLLEWTLQPI SQFVEIVPRK PAPVQKYFFQ LLEALVFELH YVPHEILRKV QCLIKESPES
PCTLVALQSV LRIASRDLLF TDIFRDSGLL GLLLAQLRKR AKILRKSAGN KESMLGVQDT
ERELTCVMLR TVVMLLRGSV RNAVVLKDHG MVPFIKIFLD DGWYREASLS ILEQLSLINA
EEYMSIIVGA LCSSTQGELQ LKLDLLQSLL RILETPKGRA AFRVSSGFNG LLSLLSDLEG
SLQEPPLQTW GMVAPSQILD LVLHTLCALS AALYLDPVNS DFFKKNGLFE KLAEDLCLLG
CFRAQEEEEA PLHSRVDTKA RPFADLLSMA FTSASPLPRK IQSCLQILSF LDSMVDGTLH
LRRDLKGSPR AGKDPVVNAQ KEDAGSDPQG NVKRWPDLEE RVDEGDAVIM HPGILCIMVR
LLPWLYHADH PQLSQEIQCS MTSHIQSLVK SEKNRQVMCE AGMLRTLVAS CRRALTASPS
PLNLGLIRIF EKLASQAIEP DVLRQFLGLG MPPLPSAAVN ILHLSFVNRG DSGGSGSQAI
AAGTAEGPTG TVLDAGPCSA VTQTIRPSGT SQGSATALQT SMSLISMTSP RNLQPQRAAL
APSFVEFDMS IEGYGCLFIP TLSTVMGSST EYLVSGGIGT GAARSFPPPR GLTFSCWFLI
GRHGTVTEGH PLRFLSLVRH LARTEQPFVC FSVSLCLDDF SLVVSTEEKE FQPLDVMEPE
DDPEPSAGRQ LRVRCGQLLA CGQWHHLAVV VTKEMKRNCT VSTYLDGQIT GSAKMLYIQA
LPGPFLSMDP SSFVDVYGYI ATPRIWKQKS SLIWRLGPTY LFEEAISMDT LEVINKLGPR
YCGNFQAVHA QVLDLDVEAM PLVAEERVSF GLHVASSSIT SVTDIRNTYN EVDSRLIAKE
MNISSRDSTM PVFLLRNCAG HLSGSLRTVG AVAVGHLGIR VFHSIPAASS LDFIGGPAIL
LGLISLATDD HTMYAAIKVL HSVLTSNVMC DHLMQHICGY QIMAFLLRKK TSLLNHRIFQ
LILSIAGTAE LGFGSSAVTN VGVFRHILCN FELWMNTADN LELSLFSHLV EILRSPREGP
RNAEVAHQAQ LIPKLIFLFN EPGLTFSKIP TIIAILGCQL RGHFNIQDLL RIGLFVVYTL
KPSSVNEREI CVDGSLDSSV PAGSQTSGKT IWLRNQLLEM LFSVISSSQL HLSSETKEEM
FLNLGPDWFL LLVQGHVHPS TTVLGLKLLL HFLSSPSLQG RFKDGLSAGS WVEHSSEGVD
IVIDNLKSHP PMPDQSPCLL PGFRVLKDFL SHHVHIPEVY LIVSTFFLQT PLTELMDGPK
DRLDAMLRWL LQKHHSEEVL RAGLCTEGAL LLLEMLKATM NQPSAGSGDD AWEQTFPASV
LQFLGLVHST YPQDPAWRAP EFLQMLAAVT FPLGTHKEPM TQPTQNASSP GAEADRDSIA
EHLQAPAKSH PTQKQLREFM QLLLREFLLE ASNPKQWLPL EVLLEAFPDS ATSQQKRDFQ
SEILLSTMEI FHTMSGGNVP LLRDSKEPQP NAEAAAAPSL ANISHFTQKL VEKLCSGMFS
ADPRHILLFV IDHIMVVIEN ASSQKDAVIS ALYSSLNKVI LYCLSKPQQS LSECLGLLSI
LGFLQEHWDI IFATYNSNVS FLLCLMHCFL LISERSYPEG FGLEPKPRMT PYHQVFLSSN
EEVREKGEED FPSLSDVQNN IQKMVRTLWQ QLVAQRRQEL EDTFKIDLSV KPGESEVKIE
EITPLWEETM LKAWQHYLAS EKKSLSNRSN VGHHSKVSSW SGSLSSAMRL MPGRQAKEPE
WKTEDFVSCI ENYRRRGQEL YASLYKDHVQ RRRCDNIKAA NAWARIQEQL FGELGLWGQT
AEATLCSRWE LDWREGPARM RKRVRHLSPL EALSPERFKE NQYRNGSVSK TSVEKQDELT
PEEAESRRDE VAVDCTQLTF FPALHESLHS EDFLELCQER QVILQELLDH EKVTQKYSLV
IVQGHLVSEG VLLFGHQHFY ICENFTLSPV GDVYCTRHCL SNISDPFIFN MCSKDRSSDQ
YSCQSHSYGQ LSELRQARFL LQDIALELFF QNGYSKFLVF HNNDRSKVFK SFCSFQPSLK
GKGITEDPLN LRRYPGSDRT MLQRWQKRDI SNFEYLMYLN TVAGRTYNDY MQYPVFPWVL
ADYTSQTLNL MNPKTFRDLS KPMGAQTKER KLKFIQRFKE VEKTEGDMTV QCHYYTHYSS
AIIVASYLVR MPPYTQAFCS LQGGSFDVAD RMFHSVKNTW ESASRDNMSD VRELTPEFFY
LPEFLINCNG VEFGCMQDGT ALGDVQLPPW ADGDPRKFIS LHRQALESDF VSANLHHWID
LIFGYKQQGS AAVEAVNTFH PYFYGDKMDL SSISDPLIRS TILGFVSNFG QVPKQLFTKP
HPARTVAGKP SPGKDAVVPA SLPSHPQPFF YNLQALRPSQ VTVKDMYLFS LGSESPKGAI
GHIVPTEKTI LAVEKNKVLL PPLWNRTFSW GFDDFSCCLG NYGSDKIIMT FENLAAWGRC
LCTVCPTPTM IITSGASTVV CVWELSIAKG RPRSLHLKQA LYGHTQAVTC LAASVIFSLL
VSGSQDCTCI LWDLDHLTHV ARLPTHQEGI SALAISDVSG TIVSCAGAHL SLWNVNGQPL
ASITTAWGPE GAITCCCVME GPAWDTNHVI ITGSQDGMVR IWRTEDMKTS VPRLAIPEEP
SQPPSPRGHR WEKNLALCRE LDISLALTGK PSKTSPAVTA LAVSRNQIKL LVGDEKGRIF
CWSAEG
//
