ID A0A3Q7SUI6_VULVU Unreviewed; 2147 AA.
AC A0A3Q7SUI6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dedicator of cytokinesis protein 9 isoform X11 {ECO:0000313|RefSeq:XP_025859451.1};
GN Name=DOCK9 {ECO:0000313|RefSeq:XP_025859451.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025859451.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025859451.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025859451.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025859451.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_025859451.1; XM_026003666.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 185..292
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 651..829
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1654..2109
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 301..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1267..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2147 AA; 245299 MW; ED0E80A5596CB65F CRC64;
MGCTTSVILF KGIRTVFERN CAYMCKQQGE NNALEYTAYH WTKEDSELLI SSCLAKPKLI
EPLDYENVIV QKKTQILNDC LREMLLFPYD DFQTATLRRQ GRYMCSTVPA DAEEEAQSLF
VTECIKTYNS DWHLVNYKFE DYSGEFRQLP NKVAKLDKLP VHVYEVDEEV DKDEDAASLG
SQKGGITKHG WLYKGNMNSA ISVTMRSFKR RFFHLLQLGD GSYNLNFYKD EKISKEPKGS
IFLDSCMGVV QNNKVRRFAF ELKMQDKSSY LLAADSEAEM EEWITILNKI LQLNFEAAMQ
EKRNGDSHED DEQSKFEGSG SGLDSYLPEL AKSTREAEIK LKSESRVKLF YLDPDAQKLD
FTSAEPEVKP FEEKFGKRIL VKCNDLSFNL QCCVAENEEG PTTNVEPFFV TLSLFDIKYN
RKISADFHVD LNHFSVRQML ATTSPALMNG GRPSSPVLQD ILQEAAMQYP KQGIFSVTCP
HPDIFLVARI EKVLQGSITH GAEPYMKSSD SSKVAQKVLK NAKQACQRLG QYRMPFAWAA
RTLFKDTSGN LDKNARFSAL YRQDSNKLSN DDMLKFLADF RKPEKMAKLP VILGNLDITI
DNVSSDFPNY VNSSYIPMKQ FETCSKTPIT FEVEEFVPCI PKHTQPYTIY NNHLYVYPKY
LKYDSQKSFA KARNIAICIE FKDSDEEDSQ PLKCIYGRPG GPVFTRSAFA AVLHHHQNPE
FYDEIKIELP TQLHGKHHLL FTFFHVSCDS SSKGSTKKKD VVETQVGYSW LPLLKDGRVV
TSEQHVPVSA NLPSGYLGYQ ELGMGRHYGP EIKWVEGSKP LLKVSTHLVS TVYTQDQHLH
NFFQYCQKTE SGAQALGSEL VKYLKSLHAM EGHVMIAFLP TILNQLFRVL TRATQEEVAV
NVTRVIIHVV AQCHEEGLES HLRSYVKYAY KAEPYIASEY KTVHEELTKA MTTILKPSAD
FLTSNKLLKY SWFFFDVLIK SMAQHLIENS KVKLLRNQRF PASYHHAVET VVNMLMPHIT
QKFRDNPEAS KNANHSLAVF IKRCFTFMDR GFVFKQINNY ISCFAPGDPK TLFEYKFEFL
RVVCNHEHYI PLNLPMPFGK GRIQRYQAFL SPTVESNDTP VDLQLDYSLT DEFCRNHFLV
GLLLREVGTA LQECREVRLI AISVLKNLLI KHSFDDRYAS RSHQARIATL YLPLFGLLIE
NVQRINVRDV SPFPVNPGST VKEESLLLPA ANPLVTPQKP GIALDNSLHK DLFGAISGIA
SPYTTSTPNI NSVRNADSRG SLISTDSGNS LPERNTEKSN SLDKHQQSGT LGNSVVRCDK
LDQSEIKSLL MCFLYILKSM SDDALFTYWN KASTSELMDF FTISEVCLHQ FQYMGKRYIA
RNQEGLGPIV HDRKSQTLPV SRNRTGMMHA RLQQLGSLDN SLTFNHSYGH SDADVLHQSL
LEANIATEVC LTALDTLSLF TLAFKNQLLA DHGHNPLMKK VFDVYLCFLQ KHQSETALKN
VFTALRSFIY KFPSTFYEGR ADMCAALCYE ILKCCNSKLS SIRTEASQLL YFLMRNNFDY
TGKKSFVRTH LQVIISVSQL IADVVGIGGT RFQQSLSIIN NCANSDRLIK HTTFSSDVKD
LTKRIRTVLM ATAQMKEHEN DPEMLVDLQY SLAKSYASTP ELRKTWLDSM ARIHVKNGDL
SEAAMCYVHV TALVAEYLTR KEADIALRPE LPLFPYSHST CQRRRRGGMF RQGCTAFRVI
TPNIDEEASM MEDVGMQDVH FNEDVLMELL EQCADGLWKA ERYELIADIY KLIIPIYEKR
RDFERLAHLY DTLHRAYSKV TEVMHSGRRL LGTYFRVAFF GQAAGFFEDE DGKEYIYKEP
KLTPLSEISQ RLLKLYSDKF GSENVKMIQD SGKVNPKDLD SKYAYIQVTH VIPFFDEKEL
QERKTEFERS HNIRRFMFEM PFTQTGKRQG GVEEQCKRRT ILTAIHCFPY VKKRIPVMYQ
HHTDLNPIEV AIDEMSKKVA ELRQLCSSAE VDMIKLQLKL QGSVSVQVNA GPLAYARAFL
DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE DQLEYQEEMK ANYREMAKEL
SEIMHEQICP LEEKTSVLPN SLHIFNAISG TPTSTMVHGM TSSSSVV
//
