ID A0A3Q7SV30_VULVU Unreviewed; 1113 AA.
AC A0A3Q7SV30;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Large proline-rich protein BAG6 {ECO:0000256|ARBA:ARBA00021614};
DE AltName: Full=BCL2-associated athanogene 6 {ECO:0000256|ARBA:ARBA00030033};
DE AltName: Full=HLA-B-associated transcript 3 {ECO:0000256|ARBA:ARBA00029739};
GN Name=BAG6 {ECO:0000313|RefSeq:XP_025846210.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025846210.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025846210.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025846210.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025846210.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Released extracellularly via exosomes, it is a ligand of the
CC natural killer/NK cells receptor NCR3 and stimulates NK cells
CC cytotoxicity. It may thereby trigger NK cells cytotoxicity against
CC neighboring tumor cells and immature myeloid dendritic cells (DC).
CC {ECO:0000256|ARBA:ARBA00002067}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
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DR RefSeq; XP_025846210.1; XM_025990425.1.
DR AlphaFoldDB; A0A3Q7SV30; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd01809; Ubl_BAG6; 1.
DR InterPro; IPR021925; BAG6.
DR InterPro; IPR048926; Bag6_BAGS.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019954; Ubiquitin_CS.
DR PANTHER; PTHR15204; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR PANTHER; PTHR15204:SF0; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR Pfam; PF12057; BAG6; 1.
DR Pfam; PF20960; Bag6_BAGS; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00299; UBIQUITIN_1; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 19..79
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 90..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..247
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..661
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 117142 MW; F02078FC789BE64C CRC64;
MEPTDSTSTT SSMEEPDSLE VLVKTLDSQT RTFIVGAQMN VKEFKEHIAA SVSIPSEKQR
LIYQGRVLQD DKKLQEYNVG GKVIHLVERA PPQTPLPSGA SSGIGSASAT HGGGPPPGTR
GPGASVHDRN ANSYVMVGTF NLPSEPRVRL VMAQHMIRDI QTLLSRMECR GGPQAQHSQP
PPQTPAVAPE PVALSSQTSE AVESEVPPRE PMEAEEVEER ASAQSPELTP SGPAPVGPTP
APETNAPNHP SPAEYVEVLQ ELQRLESRLQ PFLQRYYEVL GTAATTDYNN NQEGREEDQR
LINLVGESLR LLGNTFVALS DLRCNLACAP PRHLHVVRPM SHYTTPMVLQ QAAIPIQINV
GTTVTMTGNG TRPPPTANAE TAPPGPGQAS SLAPTSTTVE SSTEGAPPPG PAPPPTTSHP
RVIRISHQSV EPVVMMHMNI QDSGTQPGGV PSAPTGPLGP PGHGQTLGQQ VPGFPTAPTR
VVIARPTPPQ ARPSHPGGPP VSGTLQGAGL GTNASLAQMV SGLVGQLLMQ PVLVAQGTPG
MAPPPAPATA SASAGTTNTA TTAGPAPGGP AQPPPPQPSA ADLQFSQLLG NLLGPAGPGA
GGPGMASPTI TVAMPGVPAF LQGMTDFLQA AQTAPPPPPP PPPPPPAPEQ QTVPPPGSPS
GGTGSPGGLG LESLSPEFFT SVVQGVLNSL LGSLGARAGS SESIAAFIQR LSGSSNIFEP
GADGALGFFG ALLSLLCQNF SMVDVVMLLH GHFQPLQRLQ PQLRSFFHQH YLGGQEPTPG
NIRTATHTLI TGLEEYVRES FSLVQVQPGV DIIRTNLEFL QEQFNSIAAH VLHCTDSGFG
ARLLELCNQG LFECLALNLH CLGGQQMELA AVINGRIRRM SRGVNPSLVS WLTTMMGLRL
QVVLEHMPVG PDAILRYVRR VGDPPQPLPE EPMEVQGSER TSPEPQRENA SPAPGTTAEE
AMSRGPPPAP EGGGGSSHEE QDGAAAETEP WAAAVPPEWV PIIQQDIQSQ RKVKPQPPLS
DAYLSGMPAK RRKTMQGEGP QLLLSEAVSR AAKAAGARPL TSPESLSRDL EAPEVQESYR
QQLRADIQKR LQEDPNYSPQ RFPNAHRAFT DDP
//
