ID A0A3Q7SW00_VULVU Unreviewed; 773 AA.
AC A0A3Q7SW00;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Carnitine O-palmitoyltransferase 1, liver isoform {ECO:0000313|RefSeq:XP_025860013.1, ECO:0000313|RefSeq:XP_025860014.1};
GN Name=CPT1A {ECO:0000313|RefSeq:XP_025860013.1,
GN ECO:0000313|RefSeq:XP_025860014.1, ECO:0000313|RefSeq:XP_025860015.1,
GN ECO:0000313|RefSeq:XP_025860016.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025860016.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025860013.1, ECO:0000313|RefSeq:XP_025860014.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025860013.1,
RC ECO:0000313|RefSeq:XP_025860014.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025860013.1,
RC ECO:0000313|RefSeq:XP_025860014.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR RefSeq; XP_025860013.1; XM_026004228.1.
DR RefSeq; XP_025860014.1; XM_026004229.1.
DR RefSeq; XP_025860015.1; XM_026004230.1.
DR RefSeq; XP_025860016.1; XM_026004231.1.
DR STRING; 9627.ENSVVUP00000006209; -.
DR Ensembl; ENSVVUT00000008301; ENSVVUP00000006209; ENSVVUG00000004839.
DR Ensembl; ENSVVUT00000008329; ENSVVUP00000006228; ENSVVUG00000004839.
DR KEGG; vvp:112924162; -.
DR OMA; NTEHSWG; -.
DR OrthoDB; 1429709at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:1990698; F:palmitoleoyltransferase activity; IEA:Ensembl.
DR GO; GO:0009437; P:carnitine metabolic process; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:0001676; P:long-chain fatty acid metabolic process; IEA:Ensembl.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF74; CARNITINE O-PALMITOYLTRANSFERASE 1, LIVER ISOFORM; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..47
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 174..756
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 473
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 773 AA; 88197 MW; 8559A7C69BF7862F CRC64;
MAEAHQAVAF QFTVTPDGID LRLSHEALKQ IYLSGLHSWK KKFIRFKNGI ITGVYPASPS
SWLIVVVGVM STMYAKIDPS LGIIAKINRT LDTTGYMSSQ TKNVVSGILF GTGLWVALII
TMRYSLKVLL SYHGWMFAQH GKMSRATKIW MSMVKIFSGR KPMLYSFQTS LPRLPVPAVQ
DTVNRYLESV KPLMKESDFK RMTVLAQDFA VSLGPKLQWY LKLKSWWATN YVSDWWEEYI
YLRGRGPLMV NSNYYAMDLL YVLPTSIQAA RAGNAIHAIL LYRRRLDREE IKPILLLGST
VPLCSAQWER MFNTSRIPGE ETDTIQHIRD SKHIVVFHKG RYFKVWLYHD GRLLKPREIE
QQMQRILDDP SEPQPGEAKL AALTAGERVP WAKCRQAYFG RGKNKQSLDA VEKAAFFVTL
DETEQGYRKE DPDASMDSYA KSLLHGRCFD RWFDKSFTFI VFKNGKMGMN AEHSWADAPI
VGHLWEYVLA TDCFQLSYAE DGHCKGDPNP NIPYPTRLQW DIPEECQEVI ETALSSATLL
ANDVDFHSFP FHTFGKGLIK KCRTSPDAFV QLALQLAHYK DMGKFCLTYE ASMTRLFREG
RTETVRSCTT ESCNFVLAMV DPTQTVEQRL QLFQIASEKH QHLYRLAMTG SGIDRHLFCL
YVVSKYLAVD SPFLKEVLSE PWRLSTSQTP QQQVELFDLE RNPEYVSSGG GFGPVADDGY
GVSYILVGEN LINFHISSKF SSPETDSHRF GKYLKQAMSD IISLFGFSSN SKK
//
