ID A0A3Q7SYG7_VULVU Unreviewed; 534 AA.
AC A0A3Q7SYG7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX33 {ECO:0000313|RefSeq:XP_025861026.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025861026.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025861026.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025861026.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025861026.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR RefSeq; XP_025861026.1; XM_026005241.1.
DR AlphaFoldDB; A0A3Q7SYG7; -.
DR STRING; 9627.ENSVVUP00000038404; -.
DR KEGG; vvp:112924777; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_025861026.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_025861026.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_025861026.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 1..79
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 104..277
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 534 AA; 60457 MW; 94F95DD6FE8F1133 CRC64;
MLLREAISDS LLRKYSCIIL DEAHERTVHT DVLFGVVKAA QRRRKELRKL PLKVIVMSAT
MDVDLFSQYF NGASVLYLEG RQHPIQVFYT KQPQQDYLHA ALVSVFQIHQ EAPSSQDILV
FLTGQEEIEA VSKTCRDIAK HLPDGCPSML VLPLYASLPY AQQLRVFQGA PKGCRKVIIA
TNIAETSITI TGIKYVVDTG MVKAKKYNPD SGLEVLAIQR VSKTQAWQRA GRAGREDSGI
CYRLYTENEF EKFEKMTVPE IQRCNLASVL LQLLAMKVPN VLTFDFMSKP SPDHMQAAVA
QLDLLGALER KDNQLTLTPI GRKMAAFPLE PKFAKTILLS PKFHCTEEIL TIVSLLSVDS
VLYNPPSRRD EVQTMRKKFL SSEGDHITLL NIYRTFKSLG GDKDWCRENF VNSRNMMLAA
EVRAQLRDIC LKMSMPMVSC RGDVESIRRC LAHSLFMSAA ELQPDGTYTT TDSRQPVAIH
PSSALFHCRP ACVVYTELLH TSKCYMRDLC VVAAEWLYEA APDYFRRKLR ATRD
//
