ID A0A3Q7T1A0_VULVU Unreviewed; 475 AA.
AC A0A3Q7T1A0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Interferon gamma receptor 1 {ECO:0000313|RefSeq:XP_025853682.1};
GN Name=IFNGR1 {ECO:0000313|RefSeq:XP_025853682.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025853682.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025853682.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025853682.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025853682.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC {ECO:0000256|ARBA:ARBA00005399}.
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DR RefSeq; XP_025853682.1; XM_025997897.1.
DR AlphaFoldDB; A0A3Q7T1A0; -.
DR STRING; 9627.ENSVVUP00000002928; -.
DR Ensembl; ENSVVUT00000004049; ENSVVUP00000002928; ENSVVUG00000002286.
DR KEGG; vvp:112919471; -.
DR OMA; NIMLPKS; -.
DR OrthoDB; 5356432at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019955; F:cytokine binding; IEA:InterPro.
DR GO; GO:0004906; F:type II interferon receptor activity; IEA:Ensembl.
DR GO; GO:0038196; P:type III interferon-mediated signaling pathway; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR021126; IFN_gamma_rc_D2_pox/mammal.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008355; Interferon_gamma_rcpt_asu.
DR PANTHER; PTHR20859:SF5; INTERFERON GAMMA RECEPTOR 1; 1.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR Pfam; PF07140; IFNGR1_D2; 1.
DR Pfam; PF20634; IFNGR1_transm; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR PRINTS; PR01777; INTERFERONGR.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_025853682.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..475
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018745084"
FT TRANSMEM 244..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..109
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
FT DOMAIN 130..235
FT /note="Interferon gamma receptor D2"
FT /evidence="ECO:0000259|Pfam:PF07140"
FT REGION 400..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 52967 MW; 5A7036C2A9E3601E CRC64;
MALLLLLVLV LQAGCWVEMS PADPELSSVP VPTNITIEAY NFNTVLFWNY PPMPQIPVFT
VQVKNYGEAV WIDACNTSDH YCNIFPVIND PSLSLWARVK ARLGQKESAY VESKEFILCR
QGKIGPPALG IRKMENQIII DLFHPLTAIS GRQAVPIYDE NNCHTFMYTV YMKINGSETT
YTTGIEDEDD CNETQCRLTI PVSSLSLNYC ISAEGVSKEW SVVTEKSREL CITTFDGDHI
EDSVWIPIVA ALLLFLVLIL VFVYCYIKKM NPFKRESIML PKSLLSVVKN ASSETKSESK
CVSPVTYQPI VPENEKMVWE EQLSPATIVG MPTEDNAGKM EPREDLFSET EVVTTEQNTS
DMASRCPLTP GMTENSVHSN SNQSEPCVVA FNSYHSRNGS DSGVVESDSF LSDSELPPNN
KTEIKTGEQE TVMLRNTTTS FGYDKPHVLV DLLVDEGTKE SLIGYRLTAD SGEFS
//
