ID A0A3Q7T1E5_VULVU Unreviewed; 1671 AA.
AC A0A3Q7T1E5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Collagen alpha-6(IV) chain isoform X2 {ECO:0000313|RefSeq:XP_025870699.1};
GN Name=COL4A6 {ECO:0000313|RefSeq:XP_025870699.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025870699.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025870699.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025870699.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025870699.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Type IV collagen is the major structural component of
CC glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC together with laminins, proteoglycans and entactin/nidogen.
CC {ECO:0000256|ARBA:ARBA00003696}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR RefSeq; XP_025870699.1; XM_026014914.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001442; Collagen_IV_NC.
DR InterPro; IPR036954; Collagen_IV_NC_sf.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF533; COLLAGEN ALPHA-6(IV) CHAIN; 1.
DR Pfam; PF01413; C4; 2.
DR Pfam; PF01391; Collagen; 17.
DR SMART; SM00111; C4; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS51403; NC1_IV; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Collagen {ECO:0000256|ARBA:ARBA00023119,
KW ECO:0000313|RefSeq:XP_025870699.1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1671
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018554299"
FT DOMAIN 1447..1671
FT /note="Collagen IV NC1"
FT /evidence="ECO:0000259|PROSITE:PS51403"
FT REGION 109..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1671 AA; 160902 MW; BF0FEB7F39224622 CRC64;
MHPGLWLLLV TLCLTEELAG AGEKKSYGKP CGGQDCSGGC KCFPEKGARG QPGPIGIQGP
TGPQGFVGPS GLAGLKGERG SPGPLGPYGP KGDKGPMGVP GFLGINGIPG HPGQPGPRGP
PGLDGCNGTQ GAVGYPGPNG YPGLLGPPGL PGQKGSKGEP VLAQGTFKGM KGEPGLPGLD
GIIGPPGAPG SPGAVGHMGP PGLQGPPGPP GFPGPDGNMG LGFQGEKGVK GDVGLPGPAG
PPPSTGELEF MGFPKGKKGS KGEPGLPGFP GISGPPGLPG LGTAGEKGEK GIPGLPGPRG
PMGLERLQGP PGIQGKKGSS GFPGLNGLPG IKGEKGGIGL PGPDVFIDTD GAVISGYPGD
PGMPGLPGLK GDEGVQGLPG PSGIPGLPAL PGVPGALGPQ GVPGLKGDQG SPGRTTVGTA
GPPGRDGLPG LPGLQGPPGP AFETETLQNT EPGFPGLRGE RGPKGNPGLK GIKGDLGFCA
CDGGVPNTGP PGEPGMPGPP GLIGLPGLKG TRGDPGSGGA QGPSGAPGLF GPPGPAGSKG
DKGEPTFSSV SGVPGEQGDP GPQGLPGEMG TPGKDGIPGL PGLPGLPGDG GQGFPGEKGL
PGLPGERGHS GPTGPPGIGL PGSPGPRGLP GDQGIDGLPG QQGLPGLPGI TLPCIIPGTY
GLSGLPGAPG FPGPKGARGL PGTPGQPGLR GNKGEPGSPG LVHLPELPGF PGPRGEKGLP
GFPGLPGKDG LPGKLGSPGL PGPKGAPGDI FGAENGSPGE QGLQGLPGDR GLPGDSGLPG
PKGLLGKSGL LGPKGERGSP GTPGHMGVPG PPGPDGLYGS IKGKPGLPGV PGFPGPSGHP
GKKGLRGETG SPASAGKRGL PGLKGLPGSP GLIGFLGSSG LPGNTGLPGL PGPKGEKGSV
GLVGFPGMPG LPGIPGTSGI KGISGSAGRV GPSGQAGHAG EKGDRGDPGP AGVPSPRPPM
LNLRFKGDKG SRGSAGLDGF PGPRGDKGEA GPLGPPGLPG APGFPSTIKG LIGRAGLPGS
IGLRGLPGLK GSPGITGFPG IAGESGSQGL NGAPGLPGAS GLPGSKGDQG QTLGISGSPG
LKGQPGESGF KGVQGTNGLV GDVGLPGSKG EDGKVGISGD LGLPGSPGLP GIAGMRGNPG
LPGSPGRPGA TGTLGPPGLV GTKGFPGLPG LHGLNGLPGT KGTHGTPGPS ISGVPGPAGL
PGPKGEKGSP GTGIGAPGRP GSRGQKGGRG FPGLQGPAGL PGAPGLSLPS IIVGQPGDPG
RPGLDGEQGD PGDPGFPGVP GPQGPKGVQG IPGFSGLPGE LGLKGMRGEP GFMGIPGKVG
PPGDPGLPGM KGKTGPQGFS GPQGAPGQTT IAEAVQVPPG PMGLPGIDGI PGLTGDPGVQ
GPVGLQGSKG LPGVPGKDGL NGIPGPPGAL GDPGLPGLQG PPGFEGAPGK KGPFGRAGVP
GQSVRVGYTL VKHSQSEQLP LCPAGMSQLW VGYSLLFVEG QEKAHNQDLG FAGSCLPRFS
TMPFIYCNIN EVCHYARRND KSYWLSTTAP IPMMPVGQAQ IPQYISRCSV CEAPSQAIAV
HSQDITIPQC PLGWHSLWIG YSFLMHTAAG AEGGGQSLVS PGSCLEDFRA TPFIECSGAR
GTCHYFANKY SFWLTTVEER QQFQEEPVSE TLKSGQLHTR VSRCQVCMRS L
//
