ID A0A3Q7T4D6_VULVU Unreviewed; 348 AA.
AC A0A3Q7T4D6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Thrombopoietin isoform X2 {ECO:0000313|RefSeq:XP_025863081.1};
GN Name=THPO {ECO:0000313|RefSeq:XP_025863081.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025863081.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025863081.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025863081.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025863081.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the EPO/TPO family.
CC {ECO:0000256|ARBA:ARBA00005782}.
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DR RefSeq; XP_025863081.1; XM_026007296.1.
DR AlphaFoldDB; A0A3Q7T4D6; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0008283; P:cell population proliferation; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR019767; EPO/TPO_CS.
DR InterPro; IPR001323; EPO_TPO.
DR InterPro; IPR003978; Thrombopoietin.
DR PANTHER; PTHR10560; THROMBOPOIETIN; 1.
DR PANTHER; PTHR10560:SF0; THROMBOPOIETIN; 1.
DR Pfam; PF00758; EPO_TPO; 1.
DR PRINTS; PR01485; THROMBOPTN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00817; EPO_TPO; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..348
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018687261"
FT REGION 230..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..326
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 37148 MW; C863CC2872CB5B4C CRC64;
MELTELLLVV MLLLTARLDP CLPAPPACDP RLLNKMLRDS HVLHSRLSQC PDVYPLSTPV
LLPAVDFSLG EWKTQKEQTK AQDVLGAVAL LLDGVLAARG QLGPSCLSSL LGQLSGQVRL
LLGALQGLLG TQGRTTTHKD PNAIFLSFQQ LLRGKVRFLL LVAGPTLCAK QSQPTTAVPS
NTSLFLTLRK LPNRTSGLLE TNSSISARTT GSGLLKRLQG FRAKIPGLLN QTSRSLKQTP
GHLSRTHGPL NGTHGLLPGL SLTALGAPDI PLGTSDMDAL PPNLWPRYSP SPVHPPPGQY
TLFSPLPTSP IPQNPLQPPP PDPSATANST SPLQIAAHPH FQNLSQEE
//