ID A0A3Q7T524_VULVU Unreviewed; 506 AA.
AC A0A3Q7T524;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nostrin {ECO:0000313|RefSeq:XP_025849890.1};
GN Name=NOSTRIN {ECO:0000313|RefSeq:XP_025849890.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025849890.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025849890.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025849890.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025849890.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025849890.1; XM_025994105.1.
DR AlphaFoldDB; A0A3Q7T524; -.
DR STRING; 9627.ENSVVUP00000022820; -.
DR Ensembl; ENSVVUT00000030175; ENSVVUP00000022820; ENSVVUG00000016717.
DR KEGG; vvp:112916438; -.
DR OMA; YSAWCHV; -.
DR OrthoDB; 5400939at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd11823; SH3_Nostrin; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR035656; Nostrin_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065:SF62; NOSTRIN, ISOFORM H; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF46585; HR1 repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..260
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 292..372
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 438..497
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT COILED 299..333
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 506 AA; 57628 MW; 760BFEE7C1DE6F9C CRC64;
MRDPLADCSY NKVYKNLKEF SQNGENFCKQ VTSILQQRAN LEISYAKGLQ KLAVKFSKVL
QSTQKNCLVS AWAWVSEGMK SAADLHQKLG KAIELEAIKP THQVLSVHEK KRKSLDNEVE
NAANLVIGNW NQQIKAKKKL MVSTKKHEAL SHLVESSKQT VTKKEKQKLL SKLKKSTEKL
AKEDESYYQK NLAGCAARLK WENTLENCYQ SILELEKERI KLLYNNLNQY TQHISVFGQT
LTTCHTQIHC AISKIDVEKD IQALMEETAV SSTENKSEFL LTDYFEEDRN NAMNKERQES
SLKSKLLRLQ KDIEKALRDR EGLERMLKSY SKDSTFPDAE SQKITAALMD ETNLKLDLLQ
ANSYKLASVL AELEQRPQPS HPCSNSIFRW KEKQQTHSYV KISRPFLMKR LENVVSKISF
GGQRLPSSSS TASGVVQIGS GLCKALYSFQ ARQDDELNLE KGDIVTIYRK QEEGWWFGSV
NGKRGHFPAA YVEELPWDAG SPATQA
//
