ID A0A3Q7T5G6_VULVU Unreviewed; 1211 AA.
AC A0A3Q7T5G6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Guanine nucleotide exchange factor DBS isoform X1 {ECO:0000313|RefSeq:XP_025864608.1};
GN Name=MCF2L {ECO:0000313|RefSeq:XP_025864608.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025864608.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025864608.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025864608.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025864608.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_025864608.1; XM_026008823.1.
DR AlphaFoldDB; A0A3Q7T5G6; -.
DR KEGG; vvp:112927453; -.
DR OrthoDB; 4244290at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 52..224
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 631..811
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 829..945
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1111..1172
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 17..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1064
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 136228 MW; B39B3DC37EFFA067 CRC64;
MFDCWRSVLC KKTGSNIHSS LRRPDEAEKE EGDPQIDVPD VIRLVRDPPE QSHPPADEIM
HQDITPLCAA DIQDQLKKRF AYLSGGRGQD GSPVITFPDY PAFSDVPDKE FQNVMTYLTS
IPSLQDAGIG FILVIDRRQD KWTSVKASIL RIAASFPANL QLVLVLRPTG FFQRALSDLA
FKFNRDDLKM KVPVIMLSSV PELHGYIDKS QLTEDLGGTL DYCHTRWLCH RTAIESFALM
VKQTAQMLQS FGTELAETEL PNDVQSTSSV LCAHTEKKDK AKEDMRLALD EGQSILENIR
EPLAKSGEQS LNQDELDNQT TVQRLLAQLN ETEAAFDEFW AKHQQKLQQC LQLRHFEQDF
REVKSSLDAL AQKIATFTDV GNSLAHAEHL LKDLASFEEK SSASVKRAHT LSLEGEKLID
TKHYAVDSIR PKCHELQYLC DQFAAEVERR RGLLSKSLEL HGLLEASMKW CDEGIYLLAS
QPVDKCQSQD GAEAALQEIE KFLETGAENK IQELNKIYQD YESILTKDLM EHVQKVFQKQ
EGMEEMFHRR QASLKKLAAK QMRPVQPVAP RPEALTKSPC PSPGSRRGSE NSSEGSTLRR
GPYRRAKSEV SESRQGRSSS TGHEEESLAV LRRHVMNELL DTERVYVEEL LCVLEGYAAE
LDNPLMAHLM SPGLQNKKDI LFGNMEEIYH FHNRIFLREL EEYTDCPELV GRCFLERMEE
FQIYEKYCQN KPRSESLWRQ CSDCPFFQEC QRKLDHKLSL DSYLLKPVQR ITKYQLLLKE
MLKYSKSCEG AEDLQEALSS ILGILKAVND SMHLIAITGY DGNLSDLGKL LMQGSFSVWT
DHKKGHSKVK DLARFKPMQR HLFLHEKAVL FCKKREENGE GYEKAPSYSY KQSLNMAAVG
ITENVKGDVR KFEIWYNARE EVYIVQAPTA EVKAAWVSEI RKVLTSQLQA CREASQHRTL
EQSQSLPLPT PPSTSPSKGT TRNIKKLEER KTDPLSLEGY MSPSSLPKPP EKGRDDMVTS
STSESSALSR KRFTLQGFAN LKGQKASPTS PDKKPKRHEV KSDPTPFGLR GWSKTSHPLE
APEDNDGWSS AEELMNSSDA EEEGRVGPRK LVPGKYTVVV DDEKGSPEAL AVRNGDMVEV
VQEGDEGLWY VRNLSSSKES WVPASSLSAL LGMSGSAQCL SSSESSAGST LLSASSSCSE
SCGVPLSDLQ G
//
