ID A0A3Q7T6J7_VULVU Unreviewed; 1560 AA.
AC A0A3Q7T6J7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Zinc finger protein 850-like {ECO:0000313|RefSeq:XP_025850485.1};
GN Name=LOC112916849 {ECO:0000313|RefSeq:XP_025850485.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025850485.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025850485.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025850485.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025850485.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025850485.1; XM_025994700.1.
DR STRING; 9627.ENSVVUP00000038411; -.
DR KEGG; vvp:112916849; -.
DR OrthoDB; 4623148at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 2.
DR Gene3D; 6.10.140.140; -; 2.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 28.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23234:SF10; GENE 10130-RELATED; 1.
DR PANTHER; PTHR23234; ZNF44 PROTEIN; 1.
DR Pfam; PF01352; KRAB; 2.
DR Pfam; PF00096; zf-C2H2; 27.
DR SMART; SM00349; KRAB; 3.
DR SMART; SM00355; ZnF_C2H2; 28.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 17.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 3.
DR PROSITE; PS50805; KRAB; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 26.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 28.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 174..201
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 202..229
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 230..257
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 258..285
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 286..313
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 314..341
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 342..369
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 370..397
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 398..425
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 471..542
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 633..660
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 661..688
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 689..716
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 717..744
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 745..772
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 773..800
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 801..828
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 829..856
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 857..884
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1259..1286
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1287..1314
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1315..1342
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1343..1370
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1371..1398
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1399..1426
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1427..1454
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1455..1482
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1483..1510
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1511..1538
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 151..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1129..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..989
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1560 AA; 177151 MW; 547E8FB8FF937280 CRC64;
MAAVSPTARC QESVTFEDVA VIFTDEEWRH LVPIQRDLYK EVMLENYRSI VSLGLPVPRP
EVIFQLKRGD EPWIVDLHGS EERECPENIS LDWETKPEIH GTSDKEKSEG TVRGKLEGEV
PVCPKFEVHA LESELEAGKE SSAVQTCKKS LSQKENLQQE STPLKKSLTK GRDQECSNCG
KTFFDHSSLI RHQRTHTGEK PYDCHECGKA FSHRSSLSRH LMSHTGESPY ECNACGKAFF
DRSSLTVHQR IHTGEKPFKC SECGKAFFDR SSLTRHQRIH TGESPYECNQ CGKAFSQKSI
LTRHQLIHTG RKPYECNECG KAFYGVSSLN RHQKAHTGEP RYQCSECGKA FFDRSSLTQH
QKIHTGDKPY ECTECGKAFS QRCRLTRHQR VHTGEKPFEC SVCGKVFSSK SSVIQHQRRY
AKQGIDCPYY YYYYYYYYCY LANSGLGLFQ ENIEEERMAA VPLTARWQKS LKFKDVAVKF
SKDEWKQLVP AQRALYREVM LENYQDFVSL GLLVPKPDVI FQLKRGEEPW NFDFQEDEER
EVPANTFLDQ NARLESQNST QRQDVSKKAK SQKTLTEKLR KGGPLGPVLG PENLEGTRKE
HLSGKTLKKS SPKEKDSQRS TPAKKTNKKG KNFECTVCGK TLYNHLSLTR HQRTHTGEKP
YNCQECGKAF SYRSSLKKHL MSHTGKSPFE CNECEKTFYD RLTLTEHQRT HTGEKPFKCH
ECGKAFFVRS SFTRHQRIHT GESPYKCTEC GKSFTQKSIL ARHKLTHTGE RPYECKGCGK
ALFDRSSLIR HRRAHTGETP FECNECGKVF FDRSSLNQHQ KIHNGDKPYK CNECGKAFLQ
KRPLTQHQRV HTGEKPYECS VCGKVFSCKS SIVQHQRRYA RQASEYHRGA SGQQGTPIET
CESEFSAAAY IFWAGPSVGI EEGAAFRATS KGCSEGLNAL EDPLGTFVAR PALAARRAGG
RAPCRGGLGA GPSKSERPEE GRREDPRVAP GCSTRVARAF PGLPRAAERW TPGVPRAFAA
PFSRRSRHPR GPGEGVAMEP GGRGILSEDS DRLYAGNPKE NGMTTVLLTP TPQESLVIRD
MAEALTQWGQ LNPPQGDVPK KHRNLVLLGL PISKPDVISK LECGEELQRE VSKATHSDWE
TRPESQELTP EQDISEEESA PAVLIERFPK ESSSECEDSL ESQQENHEKH LIQEVVTQKK
SSRERSYQCD EFGRSFSQRS LLTQQQGERL HNCDLFKKNL KQNSDLMKHE KICAEKKPWK
CNECEKAFSY YSAFVLHQRI HTGEKPYECN ECGKAFSQSI HLTLHQRIHT GEKPYECHEC
GKAFSHRSAL IRHHIIHTGE KPYECNECGK AFNQSSYLTQ HQRIHTGEKP YECNECGKAF
SQSTFLTQHQ VIHTGEKPYK CNECGKAFSD RSGLIQHQRT HTGERPYECN ECGKAFGYCS
ALTQHQRTHT GEKPYKCNDC AKAFSDRSAL IRHQRTHTGE KPYKCKDCGK AFSQSSSLTK
HQKTHTGEKP YKCKECGKAF SQSSSLSQHQ KTHAGGKTKE YGKAFSEHSA FGQQKRIHTG
//
