ID A0A3Q7T7W6_VULVU Unreviewed; 1553 AA.
AC A0A3Q7T7W6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Band 4.1-like protein 1 isoform X8 {ECO:0000313|RefSeq:XP_025865558.1};
GN Name=EPB41L1 {ECO:0000313|RefSeq:XP_025865558.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025865558.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025865558.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025865558.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025865558.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025865558.1; XM_026009773.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR CDD; cd17201; FERM_F1_EPB41L1; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF24; BAND 4.1-LIKE PROTEIN 1; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 100..381
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..841
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..940
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1553 AA; 171062 MW; 086919AADD8000BC CRC64;
MTTETGPDSE VKKAQEEAPQ QPEAAATAAA TTPVTPAGHG GHPEANSNEK HPPQQDTRPA
EQSLDMEEKG YGEADGLSER TTPSRAQKSP QKIAKKYKSA ICRVTLLDAS EYECEVEKHG
RGQVLFDLVC EHLNLLEKDY FGLTFCDADS QKNWLDPSKE IKKQIRSSPW NFAFTVKFYP
PDPAQLTEDI TRYYLCLQLR ADIITGRLPC SFVTHALLGS YAVQAELGDY DAEEHIGNYV
SELRFAPNQT RELEERIMEL HKTYRGMTPG EAEIHFLENA KKLSMYGVDL HHAKDSEGID
IMLGVCANGL LIYRDRLRIN RFAWPKILKI SYKRSNFYIK IRPGEYEQFE STIGFKLPNH
RSAKRLWKVC IEHHTFFRLV SPEPPPKGFL VMGSKFRYSG RTQAQTRQAS ALIDRPAPFF
ERSSSKRYTM SRSLDGAEFS RPASVSENHD TGPDGDKPEE DGESGGRRSE AEEGEVRTPT
KIKELKPEQE TTPRHKQEFL DKPEDVLLKH QASINELKRT LKEPNSKLIH RDRDWERERR
LPSSPASPSP KGTPEKANES QRTQDTSPQD LAPEPGTATG WEVFTQKSLA ASPEGSEHWV
FIEREYTRPE ERLKVATTQQ EGSKTGLEDI LADGRLSKVD VLVDKFKVEV ATEETVGVRR
AKTQQQGRMI ASPEDFESVW EEGPWVRKGP GGASLAAGCT PAENLLEGSQ LRVGTGEAAI
KKRWISGGQL EGQMELRKEL EEFQAWGRPA ASGSRSAEAD VPSPASDKGG LQSFLLDPAQ
SEARGDSSDE TEPSFAERSF YLNYGEKDSE DQVLPPPLEK REEHSDALPV DDTRLELSDK
LTESSELISL DLQDSAAASS RNKDEEGKTH TASLEEGAGS PKNHGRPDGL EASVEQLGKG
PSPEQTFAED WEEAGRGVEG ECSHPASKIG TEEKAEKNPP TGWKNHSPHR GGGMCPDLPA
CTLPQAIPPN DVRKPAKPDR SNFLPQDRGL VHIQTGEPAM EDRKASAFLQ MEVIAPLPAS
PGPFQAQAAP EETFPSPAPR GSGEPLQLWD RDPFGEQSPV FPKHAHPLKE SPEPKDRIGP
LVTPDGGERR APPVASRKPR FVSEEAEGAV PPSGKQREMT SFQARGQEGS LEDISKTSVA
NKIRIFETHG AETRRASQGE TRALINELSS EASTGQVEQQ RNKLLDLGFV QLQPPGDFTG
PKATHSSVMP LATRHFREDT SHQEGCTEPV SPDSGCETAL EETPGGAGHN KSGDAVREEK
HISNLAANPP GKGGHLRFAS PLGPQRAGLR EGSEEKVKPP RPRAPESDTG DEDQDQERDA
VFLKDNHLAI ERKCSSITVS STSSLEAEVD FTVIGDYHGS AFEDFSRSLP ELDRDKSDSE
TEGLVFSRDL SKGGPSQEDE SGGIEDSPDR GACATPDMPQ FEPVKTETMT VSSLAIRKKI
EPEAVLQTRI TTMDTTQQVD GTAPGGKESI TTAPSITTET ISTTMTVKGG FSETRIEKRI
IITGDEDVDQ DQALALAIKE AKLQHPDMLV TKAVVYRETD PSPEDRDRKP QES
//
