ID A0A3Q7T862_VULVU Unreviewed; 669 AA.
AC A0A3Q7T862;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DNA mismatch repair protein Mlh1 isoform X2 {ECO:0000313|RefSeq:XP_025856817.1, ECO:0000313|RefSeq:XP_025856818.1};
GN Name=MLH1 {ECO:0000313|RefSeq:XP_025856817.1,
GN ECO:0000313|RefSeq:XP_025856818.1, ECO:0000313|RefSeq:XP_025856819.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025856817.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025856817.1, ECO:0000313|RefSeq:XP_025856818.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025856817.1,
RC ECO:0000313|RefSeq:XP_025856818.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025856817.1,
RC ECO:0000313|RefSeq:XP_025856818.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR RefSeq; XP_025856817.1; XM_026001032.1.
DR RefSeq; XP_025856818.1; XM_026001033.1.
DR RefSeq; XP_025856819.1; XM_026001034.1.
DR Ensembl; ENSVVUT00000013279; ENSVVUP00000010143; ENSVVUG00000006761.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 128..247
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 317..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 74971 MW; D351D7FE3EA47F24 CRC64;
MTFLPLVNIC FSTEALASIS HVAHVTITTK TAEAKCAYRA TYSDGKLKAP PKPCAGNQGT
QITVEDLFYN ISTRRKALKN PSEEYGKILE VVGRYSIHNS GISFSVKKQG ETVADVRTLP
NATTVDNIRS IFGNAVSREL IEVGCEDKTL AFKMNGYISN ANYSVKKCIF LLFINHRLVE
STSLRKAIET VYAAYLPKNT HPFLYLSLEI SPQNVDVNVH PTKHEVHFLH EDSILERVQQ
HIESKLLGSN SSRMYFTQTL LPGLAGPSGE VVKSTTGVTP SSTGSGNKVY AHQMVRTDSR
EQKLDAFLQP MSKALSSQLQ AVVPEDRTDV SSGRTGQQDE EMFELPEPDQ VAATNQGMEE
EATEGTSETS EKKGPPSSPG NPRKRPRESS DVEMVEDDSR KDMTAACTPR RRIINLTSVL
SLQEEINERG HETLREMLHN HSFVGCVNPQ WALAQHQTKL YLLNTTKLSE ELFYQILIYD
FANFGVLRLS EPAPLFELAM LALDSPESGW TEEDGPKEGL AEYIVEFLKK KAEMLADYFS
LEIDEEGNLI GLPLLIDNYV PPLEGLPIFI LRLATEVNWD EEKECFESLS KECAMFYSIR
KQYVSEESTL SGQQSEVCGS SANPWKWTVE HIVYKAFRSH LLPPKHFTED GNILQLANLP
DLYKVFERC
//
