ID A0A3Q7T902_VULVU Unreviewed; 691 AA.
AC A0A3Q7T902;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transducin-like enhancer protein 4 isoform X3 {ECO:0000313|RefSeq:XP_025857282.1};
GN Name=TLE4 {ECO:0000313|RefSeq:XP_025857282.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025857282.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025857282.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025857282.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025857282.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025857282.1; XM_026001497.1.
DR AlphaFoldDB; A0A3Q7T902; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF31; TRANSDUCIN-LIKE ENHANCER PROTEIN 4; 1.
DR Pfam; PF03920; TLE_N; 2.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 1..22
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT DOMAIN 22..56
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 491..532
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 533..574
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 615..646
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 56..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 74170 MW; 81E82E33AA8C9F70 CRC64;
MQRHYVMYYE MSYGLNIEMH KQHQQQVVQA VERAKQVTMA ELNAIIGQQQ LQAQHLSHGH
GLPVPLTPHP SGLQPPAIPP IGSSAGLLAL SSALGGQSHL PIKDEKKHHD NDHQRDRDSI
KSSSVSPSAS FRGAEKHRNS TDYSSDSKKQ KTEEKEIAAR YDSDGEKSDD NLVVDVSNED
PSSPRGSPAH SPRENGLDKA RLLKKDAPIS PASIASSSST PSSKSKELSL NEKSTTPVSK
SNTPTPRTDA PTPGSTSTPG LRPVPGKPAG VDPLASSLRT PMAVPCPYPT PFGIVPHAGM
NGELTSPGAA YAGLHNISPQ MSAAAAAAAA AAAYGRSPVV GFDPHHHMRV PAIPPNLTGI
PGGKPAYSFH VTADGQMQPV PFPPDALIGP GIPRHARQIN TLNHGEVVCA VTISNPTRHV
YTGGKGCVKV WDISHPGNKS PVSQLDCLNR DNYIRSCRLL PDGRTLIVGG EASTLSIWDL
AAPTPRIKAE LTSSAPACYA LAISPDSKVC FSCCSDGNIA VWDLHNQTLV RQFQGHTDGA
SCIDISNDGT KLWTGGLDNT VRSWDLREGR QLQQHDFTSQ IFSLGYCPTG EWLAVGMENS
NVEVLHVTKP DKYQLHLHES CVLSLKFAHC GKWFVSTGKD NLLNAWRTPY GASIFQSKES
SSVLSCDISV DDKYIVTGSG DKKATVYEVI Y
//
