ID A0A3Q7T9E7_VULVU Unreviewed; 3217 AA.
AC A0A3Q7T9E7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=CUB and sushi domain-containing protein 1 {ECO:0000313|RefSeq:XP_025873729.1};
GN Name=CSMD1 {ECO:0000313|RefSeq:XP_025873729.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025873729.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025873729.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025873729.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025873729.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_025873729.1; XM_026017944.1.
DR STRING; 9627.ENSVVUP00000041642; -.
DR KEGG; vvp:112934485; -.
DR OrthoDB; 4195954at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 27.
DR CDD; cd00041; CUB; 12.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 27.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 12.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF3; CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 12.
DR Pfam; PF00084; Sushi; 27.
DR SMART; SM00032; CCP; 27.
DR SMART; SM00042; CUB; 12.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 27.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 12.
DR PROSITE; PS01180; CUB; 12.
DR PROSITE; PS50923; SUSHI; 27.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3141..3162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..61
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 64..175
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 178..235
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 237..345
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 348..409
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 411..519
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 524..581
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 583..693
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 696..755
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 757..865
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 868..928
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 930..1039
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1042..1102
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1104..1212
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1215..1276
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1278..1386
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1392..1453
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1455..1563
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1566..1625
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1627..1735
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1738..1797
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1799..1910
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1909..1970
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1972..2083
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2083..2145
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2146..2207
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2208..2272
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2273..2330
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2331..2388
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2389..2446
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2447..2509
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2510..2567
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2571..2628
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2629..2687
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2688..2747
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2748..2805
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2806..2863
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2867..2925
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2926..2985
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 206..233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 552..579
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 930..957
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2301..2328
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2359..2386
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2417..2444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2480..2507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2538..2565
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2599..2626
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2658..2685
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2776..2803
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2834..2861
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2896..2923
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3217 AA; 350686 MW; 1F8F7D2BE9798CA8 CRC64;
MCPDPGIPEN GRRAGSDFRV GANVQFSCED NYVLQGSKSI TCQRVTETLA AWSDHRPICR
ARTCGSNLRG PSGIITSPNY PVQYEDNAHC VWVITTTDPD KVIKLAFEEF ELERGYDTLT
VGDAGKVGDT RTVLYVLTGS SVPDLIVSMS NQMWLHLQSD DSIASPGFKA VYQEIEKGGC
GDPGVPAYGK RAGSSFLHGD TLTFECQAAF ELVGERVITC QQNNQWSGNK PSCVFSCFFN
FTASSGIILS PNYPEEYGNN MNCVWLIISE PGSRIHLIFN DFDVEPQFDF LAVKDDGASD
VAVLGTFSGH EVPSQLASSG HVVRLEFQSD HSTTGRGFNI TYTTFGQNEC HDPGIPINGR
RFGDRFLLGS SVSFHCDDGF VKTQGSESIT CILQDGNVVW SSTVPRCEAP CGGHLTATSG
LILPPGWPGY YKDSLNCEWI IEAKPGHSIK ITFDRFQTEV NYDTLEVRDG PASSSPLIGE
YHGTQAPQFL ISTGHFMYLL FTTDNSRSSV GFLIHYESVT LESDSCLDPG IPVNGHRHGS
NFGIRSTVTF SCDPGYTLSD DEPLICERNH QWNHALPSCD ALCGGYIHRK SGTVLSPGFP
DFYPNSLNCT WTIEVSHGKG VQMTFHTFHL ESSHDYLLIT EDGSFTEPVA RLTGSVLPHT
IKAGLFGNFT AQLRFISDFS ISYEGFNITF SEYDLEPCDD PGVPAFSRRI GFHFGVGDSL
TFSCFPGYRL EGASKLTCLG GGRRVWSAPL PRCVAECGAS VKGNEGTLLS PNFPSNYDNN
HECIYKIETE AGKGIHLRAR SFQLFEGDVL KVYDGRDSSS RPLGAFTKNE LMGLVLNSTS
NHLWLEFNTN GSDTDQGFQL TYTSFDLVKC EDPGTPNYGY RIRDEGHFTD TVVLYSCNPG
YAMHGSDTLT CLSGDRRVWD KPLPSCVAEC GGEIQAATSG RILSPGYPAP YDNNLHCTWI
INADPGKTIS LHFIVFDTET AHDILKVWDG PVDSDILLKE WSGSLLPEDI HSTFSSLTLQ
FDSDFFISKS GFSIQFSTSI ASTCNDPGMP QNGTRYGDSR EPGDTITFQC DPGYQLQGQA
KITCVQLNNR FFWQPDPPTC IAACGGNLTG PAGVILSPNY PQPYPPGKEC DWRIKVNPDF
VIALIFKSFN MEPSYDFLHI YEGEDSNRPL LGSFQGSQAP ERIESSGNSL FLAFRSDASV
GLSGFAIEFK EKPREACFDP GNIMNGTRIG VDFKLGSTVT YHCDSGYKIV DPSSITCVIG
ADGKPAWSRA LPSCNAPCGG QYTGSEGVVL SPNYPHNYTA GQTCVYSISV PKEFVVFGQF
AYFQTALNDL AELFDGTHPQ ARLLSSLSGS HSGETLPLAT SNQILLRFSA KSGASARGFH
FVYQAVPRTS DTQCSSIPEP RYGRRIGSEF SAGSIVRFEC NPGYLLQGST AIRCQSVPNA
LAQWNDTIPS CIVPCSGNFT QRRGTILSPG YPEPYGNNLN CIWKIIVTEG SGIQIQVISF
ATEQNWDSLE IYDGGDMTAP RLGSFSGTTV PALLNSTSNQ LYLHFQSDIS VAAAGFHLEY
KTVGLAACQE PAIPSNGIKI GDRYMVNDVL SFQCEPGYTL QGRSHISCMP GTVRRWNYPS
PLCIATCGGT LSSMGGVILS PGFPGAYPNN LDCTWKIELP IGYGAHIQFL NFSTEANHDY
LEIQNGPYHT SPTIGQFSGA DPPSALLSTT HETLIRFYSD HSQNRQGFKL AYQAYELQNC
PDPPPFQNGY MINSDYSVGQ SISFECYPGY ILIGHPVLTC QHGINRNWNY PFPRCDAPCG
YNVTSQNGTI YSPGFPDEYP ILKDCVWLIT VPPGHGVYIN FTLLQTEAVN DYIAVWDGPD
QNSPQLGVFS GNTALETAYS STNQVLLKFH SDFSNGGFFV LNFHAFQLKK CQPPPAVPQA
EMLTEDEDFE IGDFVKYQCH PGFTLSGTDT LTCKLSAQLQ FEGSLPTCEA QCPANEVRTE
SSGVILSPGY PGNYFNSQTC SWSIRVEPNY NITIFVDTFQ SEKQFDALEV FDGSSGQSPL
LVVLSGNHTE QSNFTSRSNQ LYLRWSTDHA TSKKGFKIRY TAPYCSLTHT PKNGGILNRT
TGAVGSKVHY FCKPGYRMIG SSNATCRRSP GGIYQWDSLA PLCQAVSCGI PESPGNGSFA
GSEFTLDSRV TYECSEGFQL EAGQQAAAVC REDGLWNNTG KPLACKPVTC PSIEAQLSEH
VTWRLVSGLL SEYGAQVVLS CSPGYYLEGQ RLVQCQANGT WSIGEERPRC RVISCGSLSF
PPNGNKIGTL TVYGATAIFT CNTGYTLVGS HVRECLANGL WSGTETRCLA GHCGSPDPIV
NGHISGDGFS YRDTVVYQCN PGFRLVGTSV RICLQDHKWS GQTPVCVPIT CGHPGNPAHG
FTNGSEFNLN DVVNFTCNTG YLLQGASRAQ CRSNGQWSSA LPTCRVVNCS DPGFVENAIR
HGQQNFPESF EYGTSVMYHC KKGFYLLGSS ALTCMANGLW DRSLPKCLAI SCGHPGVPAN
AVLTGELFTY GAVVHYACKG SRDLVGNSTR VCQEDSHWSG TLPHCTGNDP GFCGDPGTPA
HGSRLGDELK TKSLMRFSCE MGYQLRGSPE RTCLLNGSWS GLQPVCEAVS CGNPGTPTNG
MIVSSDGILF SSSVIYACWE GYKTSGLMTR HCTANGTWTG TAPDCTVISC GDPGTLANGI
QFGTDFTFNK TVSYQCDPGY LMEPVTSSTI RCTKDSTWNN SKPVCKAVMC GQPPQVLHGK
VEGADFHWGA SISYSCVDGF QPSHSAILSC EGHGVWKGEV PQCLPVFCGD PGTPAEGRLS
GKSFTYKSEV FFQCKSPFVL VGSSRRSCQA DGTWSGTQPT CIDPAHNTCP DPGTPHFGIQ
NSSRGYEVGS TVFFRCRKGY HIQGSTTRTC LANLTWSGIQ TECIPHACRQ PETPAHADVR
AIDLPTFGYT LVYTCHPGFF LAAGSEHRTC KADMKWTGKS PVCKSKGVRE VNETVTKTPV
PSDVFFINSV WKGYYEYLGK RQPATLTVDW FNATSSKVNA TFLEASQVEL KLTGVYKKEE
AHLLLKAFQI KGPADIFVSK FENDNWGLAG YVSSGLERGG FTLQGDIHGK DFGKFKLERQ
DPLKSDQDSS NHYHGTSSGS VAAAILVPFF ALILSGFAFY LYKHRTRPKV QYNGYAGHEN
SNGQASFENP MYDTNLKPTE AKAVRFDTTL NTVCTVV
//
