ID A0A3Q7TA89_VULVU Unreviewed; 2192 AA.
AC A0A3Q7TA89;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Deleted in malignant brain tumors 1 protein {ECO:0000256|ARBA:ARBA00014650};
DE AltName: Full=Hensin {ECO:0000256|ARBA:ARBA00030560};
GN Name=LOC112928837 {ECO:0000313|RefSeq:XP_025866503.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025866503.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025866503.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025866503.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025866503.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DMBT1 family.
CC {ECO:0000256|ARBA:ARBA00009931}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR RefSeq; XP_025866503.1; XM_026010718.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 4.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 4.
DR Gene3D; 3.10.250.10; SRCR-like domain; 9.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48071:SF15; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00431; CUB; 4.
DR Pfam; PF00530; SRCR; 9.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00042; CUB; 4.
DR SMART; SM00202; SR; 9.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 4.
DR SUPFAM; SSF56487; SRCR-like; 9.
DR PROSITE; PS01180; CUB; 4.
DR PROSITE; PS00420; SRCR_1; 4.
DR PROSITE; PS50287; SRCR_2; 9.
DR PROSITE; PS51034; ZP_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..103
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 227..327
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 367..467
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 495..601
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 633..733
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 749..849
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 877..988
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1001..1101
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1132..1243
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1254..1354
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1380..1491
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1502..1602
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1799..1899
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1914..2155
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 140..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1625..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1663..1687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1726..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1668..1687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 28..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 41..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 72..82
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 252..316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 265..326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 296..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 392..456
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 405..466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 436..446
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 658..722
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 671..732
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 702..712
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 774..838
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 787..848
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 818..828
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1026..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1039..1100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1070..1080
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1279..1343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1292..1353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1323..1333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1527..1591
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1540..1601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1571..1581
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1824..1888
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1837..1898
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1868..1878
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 2192 AA; 233384 MW; DD131F51B7414BF9 CRC64;
MALRLVNGTE RCSGRVEVLI QGTWGTMCDD LWDLAEATVV CHQLQCGQAR EAPTGAHFGA
GSGKIVLDDV QCVGSESHLG QCVYRGEAGH NCGHLEDAGV ICAGTDGPPA PNASPGSEAP
SSVYTLIGDA LSATIARTGP STLHSTLTPA GADNSPGPTP NTETETATPS STLSGEVLTA
AVPTAEPATL PMTTTPAGDG LFAAIVTSEP AALLSTPMPL AGASMAVRLV NGTGRCSGRV
EVLIQGTWGT VCDDLWDLAE ATVVCRQLQC GQAREALTGA HFGAGSGKIM LDDVQCVGSE
SHLGQCVHRG EAGHNCGHLE DAGVICAGAD STAALPTAYK TLLPTSLVIS AAQHPPSSVP
PGGWAPVRLV GSHGRCAGRV ELFYQGVWGT VCDDLWDLPE ANIICRQLGC GWAISAPGEA
HFGEGSGNIL LDNVHCRGDE QHLEECSHIG WFSHNCGHTE DAGVICSDAE YSTVSLSDRP
LDVIAPKMAA EKSKCGRVIT NSSGAIRNPP RNEMHDNITC VWQIKANASD HILLAFPYLN
LDCTNEYFEI LDGPPSSAKS LGKTCSGSYL TYSSSSSSMT LVYFRSFNNI GKNFIAYYYS
APKEAGSRTP HLITIPTATP KTVTARPGDW PELRLVDGSG RCSGRVEVLH QGAWGTVCDD
LWDLNEAEVV CRQLGCGRAV SALGKAHFGP GSGNIFLDNL QCSGVERYLG QCAHSGWSEH
NCGHHEDASV ICSDAEESLI NSPGDWPELR LVGGSGRCSG RVEVLYQGVW GTVCDDLWDR
HEAEVVCRQL GCGRAVSALG KAHFGPGSGN IFLDNLQCSG MEHYLGQCAH SGWSEHNCDH
HEDAGVICSD AEELPPPTPQ GLSTASQDHI TGGSSSCGGV MSGPSGSFSS PLYPESYPTD
VQCVWEIHVE KKFRIELLIP TLNLEDILGC PYDSIEIFDG PRIASLSMGK FCASVAVIFF
SSSDIMTVVF RSDSMITNTG FYARFNVIPQ GEGEPENGLE LRLVGGSGRC SGRVEVLHQG
AWGTVCDDLW DLNEAQVVCR QLGCGRAIAA PGKAHFGPGS GSILLDNIQC SGSENHLGQC
PSSGWSDHNC GHHEDAGVIC SDAGAWAPDV TPASPAPIPQ GPTPPQGGSN SCGGVLSGLL
GSFSSPWYPT NYPTDVECVW MIHVAEKFHI ELVIPSLKLE DIFGCPYDFI EVFDGWQVAS
LSVGRFCAGT ELTFLSSSNI MTVVFRSDAM ITNTGFYALY NAIQQDKREN GASLRLVNGS
HRCEGRVEVL YNGTWGTVCD DNWDMTDAKV VCQQLSCGEA LSAPGQSYFD GGTGHIMLDD
VQCKGNEAKV WQCTHNGWFS HNCGHHKDAS VICSGVDGSL KVRPTDSTGD NAATDENFHC
GGLLTNNSGS FSSPWYPKKY PINVVCTWDI HVDPRAHIKL TFEVVKLENF YSCPYDFIEI
FDGPQNESFS LGKFCSGTTP VFTSSSNRLT VVFHSDAIVT NMGFFASYKS FVQDENNTDV
ALRLAGGSHQ CEGRVELHYN GTWGTVCDDS WDLRDAQVVC RQLSCGWAVS APGRAHFHQG
LGPIALDDVQ CVGTEATLWQ CLHSGWFSHN CGHHEDASVI CSASLPSSAP SAATSYPTSA
SFLKKPTEVP TSADSSAAGH PDASAPGEQP HVFQPIATEA VPDPAETTPT VASASEETTS
PVPASISAAD SVPATGIIST SAEVTSSPES FSVTVTTLTA SITTAVTSTP DTSSTSAEVT
SPSDVSSTSV EVDTPSDTSP TPGEEASSPA INLISTTVTS SPVTVSVGED MIPLPDPDLR
LVGGRSRCEG RVEVHHQGVW GTVCDDHWDI RDARVVCRLL GCGPALAALG RGRFGLGLGP
ILLDDVHCVG TEDALGHCRH SGWARHNCRH QEDAGVVCAG PAASAVPKGN ARLSCLPHLF
QVTIDRGYLR RLGYSSWDVH LNDELCRPRV TGRYLIFNIP YGRCGTVRQE SLGSLGYSNS
IRGRTRGHPG QVVVRHRVPQ LKFTCRAEGP SAVEVLPGAD VPRERVGYDV SISFLEWPLS
PPMKHMGLYP ASQRAVFLQA TLHSPDPSLR LSVDTCVASP DPHDFTTVKY DLIRQGCIKD
NTYVDLHSHQ KNTAQFKFNA FNFLSNYDVV YLQCEVAVCK VGDYSSRCSQ GCAGRGKRDV
GPVETPEEQP EHLQVVGPLE IHRGTGWRKT LV
//
