ID A0A3Q7TAD2_VULVU Unreviewed; 636 AA.
AC A0A3Q7TAD2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Plasma kallikrein isoform X2 {ECO:0000313|RefSeq:XP_025874074.1};
GN Name=KLKB1 {ECO:0000313|RefSeq:XP_025874074.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025874074.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025874074.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025874074.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025874074.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_025874074.1; XM_026018289.1.
DR AlphaFoldDB; A0A3Q7TAD2; -.
DR STRING; 9627.ENSVVUP00000017135; -.
DR Ensembl; ENSVVUT00000022567; ENSVVUP00000017135; ENSVVUG00000012628.
DR OMA; TAMYTPN; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR GO; GO:0031639; P:plasminogen activation; IEA:Ensembl.
DR GO; GO:0051919; P:positive regulation of fibrinolysis; IEA:Ensembl.
DR CDD; cd01100; APPLE_Factor_XI_like; 4.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF00024; PAN_1; 4.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00005; APPLEDOMAIN.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00223; APPLE; 4.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00495; APPLE; 1.
DR PROSITE; PS50948; PAN; 3.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Serine protease {ECO:0000256|RuleBase:RU363034}.
FT DOMAIN 111..194
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 201..284
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 292..375
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 391..627
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 636 AA; 70987 MW; 5BD36E654CC567E1 CRC64;
MISFRQAAYF TCFFATVSCG CLTQLYKNTF FKGGDLTAMY TPNVHHCQMM CTFHPRCLLF
SFLPESSTND VNKRFGCFLK DSVTETLPRM SWTSAISGHS LKQCGHQISA CHRDIHKGID
MRGVNFNVSK VKSVEECQKK CTNSIHCQFF TYATETFYNA EYRNSCLLKN GPEGTPSSIK
VLADVVSGFS LKSCALSEIG CHMNIFQHLA FSDVDVARVV TPDAFVCQTI CTYHPNCLFF
TFYTKAWHLE PQRNVCFLKT SKSGTPSSPT SQENAMSGYS LLTCKKALPE PCHSKIYSGV
DFEGEELNVT FAEGVNACQE TCTKMIRCQF FTYSLRPEDC RGEKCKCSLR LSLDGSPTGM
TYGTRVSSGY SLRLCKSGDS SVCTTKTSTR IVGGTNSSWG EWPWQVSLQV KLRAQSHLCG
GSIIGHQWVL TAAHCFDELS LPDVWRIYSG ILNLSEITKE TPFSQIKEII IHQNYKITDG
GSYDIALIKL EAPLNYTEFQ KPICLPSKDD TNTTYTNCWV TGWGFTKERG EIQNTLQKAN
IPLVPNEECQ KKYRDYEVNK QMICAGYKEG GKDACKGDSG GPLVCKHNGN WHLVGITSWG
EGCGRREQPG VYTKVAEYVD WILEKTQVGD GHTGLG
//