ID A0A3Q7TCE6_VULVU Unreviewed; 1514 AA.
AC A0A3Q7TCE6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DENN domain-containing protein 4B isoform X3 {ECO:0000313|RefSeq:XP_025852895.1};
GN Name=DENND4B {ECO:0000313|RefSeq:XP_025852895.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025852895.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025852895.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025852895.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025852895.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025852895.1; XM_025997110.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR NCBIfam; TIGR00756; PPR; 1.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF18; DENN DOMAIN-CONTAINING PROTEIN 4B; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 55..214
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 257..704
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 872..906
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 34..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1147
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1514 AA; 166100 MW; 10F09B3636D46BA0 CRC64;
MAADAVSEGG AMAEERPPRL VDYFVIAGLA GNGAPIPEET RVPEPSGPLR PPRPAEPITD
MAVIARALGE EVPQGYTCIQ SSAGGHPLEL SAGLLGGTQP VICYRRGRDK PPLVELGVLY
EGKERPKPGF QVLDTTPYSH SANLAPPGPG HPRTYLTCRR AAEGAGLHAL GITDVCLVLP
SKGEGTPHTY CRLPRNLNPG VWGPAVYLCY KVGLAKAHTL VYEAGEWPPC ASRPLLLRVP
PALVPIGWQH RHAQNSLLLC HLAFLWHLLG PPTELLGRYP EEDNEAFPLP ESVPVFCLPM
GATVECWPAH TKYPVPVFST FVLTGAAGDK VYGAALQFYE AFPRARLSER QARALGLLSA
VERGRALGGR AVRSRRAIAV LSRWPAFPAF RAFLTFLYRY SVSGPHRLPL EAHISHFIHN
VPFPSPQRPR ILVQMSPYDN LLLCQPVSSP LPLSGASFLQ LLQSLGPELA ITLLLAVLTE
HKLLVHSLRP DLLTSVCEAL VSMIFPLHWQ CPYIPLCPLV LADVLSAPVP FIVGIHSSYF
DLHDPPADVI CVDLDTNTLF QTEEKKPLSP RTLPRRPYKV LLATLTNLYQ QLDQTYTGPE
EEASLEFLLT DYEAVCGRRA RLEREVQGAF LRFMACLLKG YRDFLRPLTQ APSEGVRDVD
NLFFLQGFLK SRERSSHKLY CQLLRTQMFS QFIEECSFGS ARHAALEFFD SCVDKVHPEQ
EKPEPTPLVE LEELSGSELT VFITPPEEPA APEGSDSTPQ YCYDGFPELR AELFESPHEQ
PGALPVPGPS RSAPSSPAPR RTKQEMKVAQ RMAQKSAAVP ELWARCLLGH CYGLWFLCLP
AYVRSAPSRV QALHTAYQVL RQMESRKVVL PDEVCYRVLM QLCSHYGQPV LSVRVMLEMR
RAGIVPNTIT YGYYNKAVLE SKWLSGTPGG RLRWAKLRNV VLGAAQFRQP LRERRRQQQQ
QQQQQQQQQQ AAAQEAGSSQ TEPYLERHSP TRPLQRQTTW AGQSFRDPAS PTGRLVKSGS
LGSARGAQPT VEAGVAHMIE ALGVLEPRGS PVPWHDGSLS DLSLTGEELA PGGSLEDSGS
ALGAQSTEAL EGPSGLASKA SGRQDEASTP RRGLGARLQQ LLTPSRRSPA SHVPPPELPP
DLPPPARRSP MDSLLRPRER PGSTASEILL SSCSSCRACD SLVYDEEIMA GWAPDDSNLN
TICPFCACPF VPLLSVQTLD SRPSAPSPKP APAGASNSKD APTPGGSGPV LSDRRLCLAL
DEPQLCNGHM GAVPRRVEGG AWAYLSPLVL RKELESLVEN EGSEVLALPE LPAAHPIIFW
NLLWYFQRLR LPNILPCLVL ASCDGPPLPQ APSPWLMPDP ASVQVRLLWD VLTPDPSSCP
PLYVLWRIHS QIPQRVVWPG PIPAPLSLDL LESVLRHVGL NEVHKAVGLL LETLGPPPAG
LHLQRGIYRE ILFLTMAALG KDHVDIVAFD KKYKSAFNKL ASSMGKEELR QRRAQMPSPK
AIDCRKCFGA PLEC
//
