ID A0A3Q7TCP4_VULVU Unreviewed; 558 AA.
AC A0A3Q7TCP4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Signal peptide peptidase-like 2B isoform X1 {ECO:0000313|RefSeq:XP_025875004.1};
GN Name=SPPL2B {ECO:0000313|RefSeq:XP_025875004.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025875004.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025875004.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025875004.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025875004.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004366}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004366}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00004366}.
CC -!- SIMILARITY: Belongs to the peptidase A22B family.
CC {ECO:0000256|ARBA:ARBA00006859}.
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DR RefSeq; XP_025875004.1; XM_026019219.1.
DR AlphaFoldDB; A0A3Q7TCP4; -.
DR STRING; 9627.ENSVVUP00000003434; -.
DR KEGG; vvp:112935485; -.
DR OrthoDB; 907832at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR CDD; cd02129; PA_hSPPL_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007369; Peptidase_A22B_SPP.
DR InterPro; IPR006639; Preselin/SPP.
DR PANTHER; PTHR12174; SIGNAL PEPTIDE PEPTIDASE; 1.
DR PANTHER; PTHR12174:SF39; SIGNAL PEPTIDE PEPTIDASE-LIKE 2B; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04258; Peptidase_A22B; 1.
DR SMART; SM00730; PSN; 1.
DR SUPFAM; SSF52025; PA domain; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 145..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..122
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT REGION 482..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 61308 MW; E58F2785E688E7CF CRC64;
MVHVVSETGG PRGKDYCILY NPQWAHLPHD LGKASLLQLR DWTASVLCSP PDLPTKGFSN
QIPLVARGNC TFYEKVRLAQ GGGARGLLIV SKETLVPPGG NKTQYEEIGI PVALLSYRDM
LDIFKNFGRA VRAALYAPNE PMLDYNMVII FVMAVGTVAL GGYWAGSRDV KKRYMKHKRD
DGPEKQEDEA VDVTPVMICV FVVMCCSMLV LLYYFYDQLV YVIIGIFCLS SSTGLYSCLA
PLVQRLPFGR CRVPDNSLPY FHKRPRVSML LLALLCLAVS VVWGIFRNED QWAWVLQDAL
GVAFCLYMLK TIRLPTFKAC TLLLLVLFVY DVFFVFITPF LTKSGNSIMV EVATGPSDSA
THEKLPMVLK VPRLNASPLA LCDRPFSLLG FGDILVPGLL VAYCHRFDIQ VQSSRVYFVA
CTVAYGIGLL VTFMALALMQ RGQPALLYLV PCTLITSCAL ALWRRELGMF WTGSGFVKDL
PQSPWAPSSA DSPQPRKDSD TGLSQPPPGE ELAKCPLPHG QPPELSVPEE TGAGASPQEP
VSPEGHAPEP VSVVGTSA
//
