ID A0A3Q7TDD4_VULVU Unreviewed; 916 AA.
AC A0A3Q7TDD4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Solute carrier family 12 member 9 {ECO:0000256|ARBA:ARBA00019359};
GN Name=SLC12A9 {ECO:0000313|RefSeq:XP_025875302.1,
GN ECO:0000313|RefSeq:XP_025875303.1, ECO:0000313|RefSeq:XP_025875304.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025875304.1};
RN [1]
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025875303.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025875303.1};
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025875302.1, ECO:0000313|RefSeq:XP_025875304.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025875302.1,
RC ECO:0000313|RefSeq:XP_025875304.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025875302.1,
RC ECO:0000313|RefSeq:XP_025875304.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_025875302.1; XM_026019517.1.
DR RefSeq; XP_025875303.1; XM_026019518.1.
DR RefSeq; XP_025875304.1; XM_026019519.1.
DR STRING; 9627.ENSVVUP00000032453; -.
DR Ensembl; ENSVVUT00000042957; ENSVVUP00000032453; ENSVVUG00000023538.
DR KEGG; vvp:112935690; -.
DR OMA; VANVFSC; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF98; SOLUTE CARRIER FAMILY 12 MEMBER 9; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..535
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 547..634
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 644..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 96197 MW; 59FDD1EA4B1E9929 CRC64;
MASENSPLLA YRLLGDEGVA FSANGGGGAG GASARKLSTF LGVVVPTVLS MFSIVVFLRI
GFVVGHAGLL QALAMLLVAY FILALTVLSV CAIATNGAVR GGGAYFMISR TLGPEVGGSI
GLMFYLANVC GCAVSLLGLV EAVLDVFGAD SSPSSGLQVL PQGYGWSLLY GSLLLGLVGG
VCTLGAGLYA RASFLTFLLV SGSLASVLVS FVAVGPRSIP LAPRPSPNGS TPQPQVGHFT
GFNSSTLKAN LGAGYAKDYT TGAMMTFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL
GTIIAVTYTF FIYTLLFFLS SFTCDRTLLQ EDYGFFRAIS LWPPLVLIGI YATSLSASMS
SLIGASRILH ALAQDDLFGV ILAPAKVVSR TGNPWGAVLY SWGLVQLVLL AGKLNTLAAV
VTVFYLVAYA AVDLSCLSLE WASAPNFRPT FSLFSWHTCL LGVASCLLMM FLISPGAAGG
SLLLMGLLSA LLTARGGPSS WGYVSQALLF HQVRKYLLRL DVRKEHVKFW RPQLLLLVGN
PRGALPLLRL ANQLKKGGLY VLGHVTLGDL DCLPSDPVQP QYGAWLSLVD RAQVKAFVDL
TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAAPQDH FLTDPAFSEA TDGTQEGGSP
ALSTLFPPPR APGSPRALSP QDYVATVADA LKMNKNVVLA RACGALPPER LSRGSGGTSQ
PHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ MATILGMVPA WHSARLRIFL CLGPREAPGA
AEGRLRALLS QLRIRAEVQE VVWGEGAGAG EPEEEEEEGD FVNGRRGDAE AEALACSANA
LVRAQQGRSR GGGPGGPEGG DGEGGPATAL TFLYLPRPPA DPARYTRYLA LLETLTHDLG
PTLLIHGVTP VTCTDL
//
