ID   A0A3Q7TDE4_VULVU        Unreviewed;       376 AA.
AC   A0A3Q7TDE4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Integral membrane protein GPR180 isoform X2 {ECO:0000313|RefSeq:XP_025859412.1};
GN   Name=GPR180 {ECO:0000313|RefSeq:XP_025859412.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025859412.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025859412.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025859412.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025859412.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_025859412.1; XM_026003627.1.
DR   AlphaFoldDB; A0A3Q7TDE4; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR   InterPro; IPR047831; GPR180/TMEM145.
DR   InterPro; IPR019336; GPR180/TMEM145_TM.
DR   PANTHER; PTHR23252:SF29; INTEGRAL MEMBRANE PROTEIN GPR180; 1.
DR   PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR   Pfam; PF10192; GpcrRhopsn4; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..376
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018612711"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        246..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        290..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          143..298
FT                   /note="GPR180/TMEM145 transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF10192"
SQ   SEQUENCE   376 AA;  41875 MW;  59E3E1EBE8F81436 CRC64;
     MGGLRLLAVA LTCCWWPPGS QGKTLRGSFS SAAARDAQGQ SIGHFEFHGD HALLCVRINN
     IAVAVGKEAK LYLFQAQEWL KLQESGHGYS CGEKLSKAQL TMTMNQTEHN LTVSQIPYPQ
     TWHVFYADKY TCRDDNENSQ VEDISFEMML LNPDAEGNPF DHFGAGESGL HEFFFLLVLV
     YFVLACIYAQ SLWQAIKKGG PMHVILKVLT TALLLQASSA LANYIHFSSY SKDGIGIPFM
     GSLAEFFDIA SQIQMLYLLL SLCMGWTIVR MKKSQSRPLQ WDSTPASTGI AVFIVITQGC
     ILWFLCHPGL ACISVIFSDY QRDKVITIGV ILCQSVSMVI LYRLFLSHSL YWEVSSLSSV
     TLPLTISSGH KSRPHF
//