ID A0A3Q7TDS4_VULVU Unreviewed; 632 AA.
AC A0A3Q7TDS4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Leucine-rich repeat and WD repeat-containing protein 1 {ECO:0000256|ARBA:ARBA00015536};
DE AltName: Full=Origin recognition complex-associated protein {ECO:0000256|ARBA:ARBA00033046};
GN Name=LRWD1 {ECO:0000313|RefSeq:XP_025875494.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025875494.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025875494.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025875494.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025875494.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the LRWD1 family.
CC {ECO:0000256|ARBA:ARBA00007545}.
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DR RefSeq; XP_025875494.1; XM_026019709.1.
DR AlphaFoldDB; A0A3Q7TDS4; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR24370:SF10; LEUCINE-RICH REPEAT AND WD REPEAT-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24370; OPTICIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00369; LRR_TYP; 2.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 372..406
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 125..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 69271 MW; 13266620A300C472 CRC64;
MGPLSARLLM QRGRPKSDRL GKIRSLDLSG LKLLSEHLDP KLLSRLKQLQ ELDLSNNQLE
TLPANLGLSH LRVLRCANNQ LGDVTALCQF PQLEELSLEG NPFLTVRMIS EELVASGGIQ
VREADIPERP PKATAAREPR AKPAALKRPD DTPLSLSPNK RVCTSSSSAH VEGSDGSQPT
LEPLHFLQCH SKNNSPRDLE TQLWACAFEP AWEEGMSLVG RQGRARPRGR SRTSYLDWAP
GNATCRGQGL SEWGAWERPP TRCCKDRKKE LQGQTSQNVF IGLILNTGQA GATSQTVATC
GGEAVCVIDC QTGIVLHKYK APGEEFFSVA WTALTVVTQA GHKKRWSVLA AAGLRGLVRL
LHVQAGFCCG VIRAHKKAIA TLCFSPTHET HLFTASYDKR IILWDLGVPN HDYEFQASQL
LTLDTTSIPL RLCPVASCPD TYLLAGCEGG CCCWDVRLDQ PQKRRVCEVE FVFSEGAEAA
GRRVDGLAFV NEDVVASKGN SLGTICLWSW SQTWVGRGKQ STLAVVVLAR LQWSPTKLAY
FSLSTCPAGE GIVLCGDEEG NVWVYDVRHI LTQPSPLPAA PQAPTQILKW PQPWALGQMV
TKTMVNTVVA NPTFTYLTAL TDSNIVAIWK RQ
//
