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Database: UniProt
Entry: A0A3Q7TEN8_VULVU
LinkDB: A0A3Q7TEN8_VULVU
Original site: A0A3Q7TEN8_VULVU 
ID   A0A3Q7TEN8_VULVU        Unreviewed;      1544 AA.
AC   A0A3Q7TEN8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
GN   Name=MADD {ECO:0000313|RefSeq:XP_025859822.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025859822.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025859822.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025859822.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025859822.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the MADD family.
CC       {ECO:0000256|ARBA:ARBA00005978}.
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DR   RefSeq; XP_025859822.1; XM_026004037.1.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR039980; MADD.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Kinase {ECO:0000313|RefSeq:XP_025859822.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Transferase {ECO:0000313|RefSeq:XP_025859822.1}.
FT   DOMAIN          14..565
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          106..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          677..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          828..878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          988..1017
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1071..1161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..169
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        689..719
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        774..799
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1078..1133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1544 AA;  171342 MW;  6D511AA84DE1FB91 CRC64;
     MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHAEFPLPP DVVFFCQPEG
     CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS FQKRMPKDKG DGGAGSRGKE
     GPRATCAPEE IGTESSESGL SLQPPSADSA PNVTQSPRGK PRAKTGSRSR NSTLTSLCVL
     SHYPFFSTFR ECLYTLKRLV DCCSERLLGK KLGIPRGIQR DTMWRIFTGS LLVEEKSSAL
     LHDLREIEAW IYRLLRSPVP VSGQKRVDIE VLPQELQQAL TFALPDPSRF TLVDFPLHLP
     LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF PVIPLLPTCM
     ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD SNRVIAPTNA EMLPILPEPE
     SLELKKHLKQ ALASMSLNTQ PILNLEKFHE GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN
     DVDSVDVATR VAMVRFFNSP NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE
     KLARTQAVEY FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ
     LAEALSVPRE RDSDSDPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI NGDTPNVDPL
     THAALGDASE VEIDELQNQK ESEEPGPDSE NSQENPPLRS SSSTTASSSP STVIHGANSE
     PADSTEVDDK AAVGVSKPPP TVPPSIGKSN VDRRQTEIGE GAQKMLRPNS LKLASDSDAE
     SDSRASSPTS TVSNTSTEGF GGIMSFASSL YRNHSTSFSL SNLTLPTKGA REKTTPFPSL
     KGNRRALVDQ KSSVIKHSPT VKREPPSPQG RSSNSSENQQ FLKEVVHSVL DGQGVGWLNM
     KKVRRLLESE QLRVFVLSKL NRTVQSEDDA WQDVIPDVEI SRKVYKGMLD LLKCTVLSLE
     QSYAHAGLGG MASIFGLLEI AQTHYYSKEP DKRKRSPTES VNTPVGKDPG LAGRGDPKAM
     AQLRVPQLGP RAPSAAGKGP KELDTRSLKE ENFVASVGPE VIKPVFDLGE TEEKKSQISA
     DSGVSLTSGS QRTDTDSVIG VSPAVMIRSS SQDSEVSTVS NSSGETLGAD SDLSSNAGDG
     PGGEGSTHLA SSRGTLSDSE IETNSATSTI FGKAHSLKPS VKEKLVGSPV RSSEDVSQRV
     YLYEGLLGKE RSTLWDQMQF WEDAFLDAVM LEREGMGMDQ GPQEMIDRYL SLGEHDRKRL
     EDDEDRLLAT LLHNLISYML LMKVNKNDIR KKVRRLMGKS HIGLVYSQQI NEVLDQLVNL
     NGRDLSIRSS GSRHMKKQTF VVHAGTDTNG DIFFMEVCDD CVVLRSNIGT VYERWWYEKL
     INMTYCPKTK VLCLWRRNGS ETQLNKFYTK KCRELYYCVK DSMERAAARQ QSIKPGPELG
     GEFPVQDMKT GEGGLLQVTL EGINLKFMHN QVFIELNHIK KCNTVRGVFV LEEFVPEIKE
     VVSHKYKTPM AHEICYSVLC LFSYVAAVRS SEEDLRTPPR PVSS
//
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