ID A0A3Q7TGK5_VULVU Unreviewed; 591 AA.
AC A0A3Q7TGK5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Netrin-4 isoform X3 {ECO:0000313|RefSeq:XP_025868843.1, ECO:0000313|RefSeq:XP_025868844.1};
GN Name=NTN4 {ECO:0000313|RefSeq:XP_025868843.1,
GN ECO:0000313|RefSeq:XP_025868844.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025868843.1};
RN [1]
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025868844.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025868844.1};
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025868843.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025868843.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025868843.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; XP_025868843.1; XM_026013058.1.
DR RefSeq; XP_025868844.1; XM_026013059.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03578; NTR_netrin-4_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR035811; Netrin-4_NTR.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF282; NETRIN-4; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 1..224
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 295..357
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 358..411
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 469..590
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 325..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 385..394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 591 AA; 66193 MW; AE59E39A42A79668 CRC64;
MGNLALGRKL WADTTCGQNA TELYCSYSEN TDLTCRQPKC DKCNAAQPHL AHLPAAMADS
SFRFPRTWWQ SAEDVHREKI QLDLEAEFYF THLIMVFKSP RPAAMVLDRS QDFGKTWKPY
KYFATNCSAT FGLEDDVFKK GAICTSRYSH PFPCTGGEVI FRALSPPYDA ENPYSAKVQE
QLKITNLRVQ LLKRQSCPCQ RNDLTAKPQH FTHYAIYDFI VKGSCFCNGH ADQCIPVDGF
RPVKAPGAFH VVHGKCMCKH NTAGTHCQHC APLYNDRPWE AADGKTGSPK ECRTCKCNGH
ADTCHFDINV WEASGNRSGG VCNDCQHNTE GQHCQRCKPG FYRDLRRPFS APDACKMCSC
HPVGSAALPF SSVTFCDPSN GDCPCKPGVA GPHCDRCMVG YWGFGDYGCR PCDCAGSCDP
LTGDCISSST DIDWYHEIPD FHSTHNKSEP TWEWEDEQGF SALRHSGKCE CKEQVLGNSK
AFCGMKYSYV LKIKILSAHD KGSHAEVNVK IKKVLKSTKL KILRGKRTLY PESWTNRGCT
CPILNPGLEY LVAGHEDVRT GKLVVNMKSF VQHWKPSLGR KVMDILKREC K
//
