ID A0A3Q7TGV7_VULVU Unreviewed; 1024 AA.
AC A0A3Q7TGV7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Tudor domain-containing protein 7 {ECO:0000256|ARBA:ARBA00013425};
GN Name=TDRD7 {ECO:0000313|RefSeq:XP_025868946.1,
GN ECO:0000313|RefSeq:XP_025868947.1, ECO:0000313|RefSeq:XP_025868948.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025868948.1};
RN [1]
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025868946.1,
RC ECO:0000313|RefSeq:XP_025868947.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025868946.1,
RC ECO:0000313|RefSeq:XP_025868947.1};
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025868948.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025868948.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025868948.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of specific cytoplasmic RNA granules involved in
CC post-transcriptional regulation of specific genes: probably acts by
CC binding to specific mRNAs and regulating their translation. Required
CC for lens transparency during lens development, by regulating
CC translation of genes such as CRYBB3 and HSPB1 in the developing lens.
CC Also required during spermatogenesis. {ECO:0000256|ARBA:ARBA00025023}.
CC -!- SUBUNIT: Found in a mRNP complex, at least composed of TDRD1, TDRD6,
CC TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17.
CC Interacts with CABLES1, CDK17 and PIWIL1.
CC {ECO:0000256|ARBA:ARBA00025868}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TDRD7 family.
CC {ECO:0000256|ARBA:ARBA00007740}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025868946.1; XM_026013161.1.
DR RefSeq; XP_025868947.1; XM_026013162.1.
DR RefSeq; XP_025868948.1; XM_026013163.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd09973; LOTUS_2_TDRD7; 1.
DR CDD; cd09974; LOTUS_3_TDRD7; 1.
DR CDD; cd20427; Tudor_TDRD7_rpt1; 1.
DR CDD; cd20428; Tudor_TDRD7_rpt2; 1.
DR CDD; cd20429; Tudor_TDRD7_rpt3; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 2.40.50.90; -; 3.
DR Gene3D; 3.30.420.610; LOTUS domain-like; 2.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR037978; TDRD7_LOTUS_3.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047448; Tudor_TDRD7_rpt2.
DR InterPro; IPR047449; Tudor_TDRD7_rpt3.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22948:SF29; TUDOR DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00567; TUDOR; 3.
DR SMART; SM00333; TUDOR; 3.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51644; HTH_OST; 2.
DR PROSITE; PS50304; TUDOR; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022871};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 159..228
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 263..332
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 439..496
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT DOMAIN 629..686
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 51..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 115302 MW; E4649216DBEA889A CRC64;
MACTETARIA QLVARQRSSK RKTGRQVNCQ MRVKKTMPFF LEGKPKATLR QPGFSSDFSV
SKKPNPTLLR DKGNSLGVKS DAEMPPYTLH TTLRSEVFKD VPVQRHVTMS TNNRFSPKAS
LPPPFQMHLS RTCAKEMSDN LNQTVEKPNV TPPASYTYKM DEVQNRIKEI LNKHNNGIWI
SKLPHFYKEL YKEELNQGIL QQFEHWPHIC TVEKPGSGGQ DLLLYPAKRK QLLRSELDGE
KVPPSPLPAP KQIPPLKGCP AVMPGDFKEK VAELLTKYSS GLWASALPKA FEDMYKMKFP
EDALKNLASL SDVCTIDYIS GNPQKAILYA KLPLPTDKIL KDSGQAHGDY DIKSMIEQEY
LQIEENIAKS VDTFLENTAV PPLIIPTEAS PSVLVVELSN TNEVVIRYVG KDYSAAQELM
EDEMKEYYSK NPKVTPVQTV HVGQLLAVNA EEDAWLRAQI ISTEENRIKV CYVDYGFSEN
IEKSKAYKLN PKFCSLSFQA TKCKLAGLEV LSDDPDLVKV VESLTCGKIF AVEILEKADI
PLVVLYDTSG DDDVNINATC LKAICDKSLE AHLQIDAMYT NVRVTNICSD GTLYCQVPCK
GLNKLNDLLH KIEDYFHCKH MTSEYFVSLP FCGKVCLFHC KGKWLRVEIT NVHSSRALDV
QFLDSGTVTS VKVSELREIP PRFLQEIIVI PPQAIKCCLA DLPQSIGMWT PDAVLWLRDS
VLNCSDCSIK VTKVDETRGI AHIYLFTPKN FPDPHRSINR QITNADLWKH QKDVFLSAIS
SGASSPNSKS GSTPVPGSTG DNFRKSLTDA IKKSVVDHTS SFSVEELPPP VHLSKPGEHM
DVYVPVACHP GYFVIQPWQE IHKLEVLMEE MILYYSVSEE RHVAVEKDQV YAAKVENKWH
RVLLKGILTN GLVSVYELDY GKHELVNIRK VQPLAAVFRK LPFQAVTAQL AGVKCNQWSE
EASMVFRNHV EKKPLVALVQ TVIENANPWD RKVVVYLVDT SLPDTDIWIH DFMSEYLVEL
SKVN
//
