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Database: UniProt
Entry: A0A3Q7TI40_VULVU
LinkDB: A0A3Q7TI40_VULVU
Original site: A0A3Q7TI40_VULVU 
ID   A0A3Q7TI40_VULVU        Unreviewed;      1043 AA.
AC   A0A3Q7TI40;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Disabled homolog 2-interacting protein isoform X2 {ECO:0000313|RefSeq:XP_025865026.1};
GN   Name=DAB2IP {ECO:0000313|RefSeq:XP_025865026.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025865026.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025865026.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025865026.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025865026.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_025865026.1; XM_026009241.1.
DR   AlphaFoldDB; A0A3Q7TI40; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd04013; C2_SynGAP_like; 1.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR021887; DAB2P_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF12004; DAB2P_C; 1.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT   DOMAIN          1..78
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          69..187
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          247..439
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          531..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          567..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          611..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          657..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          697..719
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          749..852
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          869..888
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1017..1043
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          985..1012
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        567..589
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        703..719
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        751..769
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        770..789
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        791..810
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        873..888
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1043 AA;  115039 MW;  6FBB54F6F67B7CC1 CRC64;
     MPRLKESRSH ESLLSPSSAV EALDLSMEEE VVIKPVHSSI LGQDYCFEVT TSSGSKCFSC
     RSAAERDKWM ENLRRAVHPN KDNSRRVEHI LKLWVIEAKD LPAKKKYLCE LCLDDVLYAR
     TTGKLKTDNV FWGEHFEFHN LPPLRTVTVH LYRETDKKKK KERNSYLGLV SLPAASVAGR
     QFVEKWYPVV TPNPKGTKGP GPMIRIKARY QTITILPMEM YKEFAEHITN HYLGLCAALE
     PILSAKTKEE MASALVHILQ STGKVKDFLT DLMMSEVDRC GDNEHLIFRE NTLATKAIEE
     YLKLVGQKYL QDALGEFIKA LYESDENCEV DPSKCSAADL PEHQGNLKMC CELAFCKIIN
     SYCVFPRELK EVFASWRQEC SSRGRPDISE RLISASLFLR FLCPAIMSPS LFNLLQEYPD
     DRTARTLTLI AKVTQNLANF AKFGSKEEYM SFMNQFLEHE WTNMQRFLLE ISNPETISNT
     AGFEGYIDLG RELSSLHSLL WEAVSQLEQS IVSKLGPLPR ILRDVHTALN TPGSGQLTGT
     NDLASTPGSG SSSISAGLQK MVIENDLSGS SGVQPSPARS SSYSEANEPD LQMANGGKSL
     SMVDLQDART LDGEAGSPAG PDALTTDGQT PASQLAAGWP ARTAPASLAG LATVRRAGQT
     PTTPGTSEGA PGRPQLLAPL SFQNPVYQMA AGLPLSPRGL GDSGSEGHSS LSSHSNSEEL
     TAAAKLGSFS SAAEELSRRP GDLARRQMSL TEKGGQPTVP RQNSAGPQRR IDQPPPPPPP
     PPPAPRGRTP PTLLSTLQYP RPSSGTLASA SPDWAGPGAR LRQPSSSSKG DSPELKPRVV
     HKQGPSPVSP NALDRTAAWL LTMNAQLLED EGLGPDPPHR DRLRSKEELS QAEKDLAVLQ
     DKLRISTKKL EEYETLFKCQ EETTQKLVLE YQARLEEGEE RLRRQQEDKD IQMKGIISRL
     MSVEEELKKD HAEMQAAVDS KQKIIDAQEK RIASLDAANA RLMSALTQLK ERYSMQARNG
     VSPTNPTKLQ ITENGEFRNS SHC
//
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