ID A0A3Q7TIC8_VULVU Unreviewed; 743 AA.
AC A0A3Q7TIC8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Threonine synthase-like 1 {ECO:0000313|RefSeq:XP_025869463.1, ECO:0000313|RefSeq:XP_025869464.1};
GN Name=THNSL1 {ECO:0000313|RefSeq:XP_025869463.1,
GN ECO:0000313|RefSeq:XP_025869464.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025869463.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025869463.1, ECO:0000313|RefSeq:XP_025869464.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025869463.1,
RC ECO:0000313|RefSeq:XP_025869464.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025869463.1,
RC ECO:0000313|RefSeq:XP_025869464.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
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DR RefSeq; XP_025869463.1; XM_026013678.1.
DR RefSeq; XP_025869464.1; XM_026013679.1.
DR STRING; 9627.ENSVVUP00000014054; -.
DR Ensembl; ENSVVUT00000018431; ENSVVUP00000014054; ENSVVUG00000010300.
DR KEGG; vvp:112931160; -.
DR OMA; FNRCQHL; -.
DR OrthoDB; 5309433at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR CDD; cd00464; SK; 1.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR HAMAP; MF_00109; Shikimate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR000623; Shikimate_kinase/TSH1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF01202; SKI; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR PRINTS; PR01100; SHIKIMTKNASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 247..318
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT MOD_RES 351
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 743 AA; 83314 MW; DA7B698AF49AFEF4 CRC64;
MLHFNRCPHL KQIAQKCFSS IHVRTDKHVQ LFLSRTFALA EFRKSWHSTH SVVGDKNIIL
MGPPGAGKTT VGRIIGQKLG CCVIDVDDDI LEKTWNMSVS EKLQDVGNEQ FLEEEGKAVL
NFSASGSVIS LTGSNPMHDA SMWHLKKNGI IVYLDVPLID IVSRLKLMKI DRIVGQNAEI
SLKDLLKFRR QYYKKWYDTR VFCESGASPE EVADKVLKAV KRYQDVDSET FISTRHIWPK
DRERKVSTKF FSEAVIEGLA SDGGLFVPEK EFPKLNCREW KSLVGATYIE RAQILLEKCI
HPADIPAARL GEMIETAYGE NFACSKIAPV RHLSGNQFIL ELFHGPTGSF KDLSLQLMPH
LFAHCIPPSC NYMILVATSG DTGSAVLNGF SRINKNDKQR IAVATFFPEN GVSDFQKAQI
IGSQKENGWA VGVKSDFDFC QTAVKGIFKD SDFTGFLIME YGTVLSSANS INWGRLLPQV
VYHASAYLDL VSQGFISFGS PVDVCIPTGN FGNILAAVYA KMMGIPIRKF ICASNQNHVL
TDFIKTGHYD LRERKLTQTF SPAIDILKAS NLERHLHLVA DKDGELMTKL FSQLEEQHHF
QIEKMLVEKL QQDFVADWCS EGECLAAIHS TYNTSGYILD PHTAVAKVVA DRMQDKTCPV
IVSSTAHYSK FAPAIMQALK IEEINHNSSS QLYLLSSYNA LPPPHEALLE RTKQQEKMEY
QVCAADVNVL KSHVEKLIQS QFI
//
