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Database: UniProt
Entry: A0A3Q7TNN8_VULVU
LinkDB: A0A3Q7TNN8_VULVU
Original site: A0A3Q7TNN8_VULVU 
ID   A0A3Q7TNN8_VULVU        Unreviewed;      1956 AA.
AC   A0A3Q7TNN8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|RefSeq:XP_025856775.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025856775.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025856775.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025856775.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025856775.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC       excitable membranes. Assuming opened or closed conformations in
CC       response to the voltage difference across the membrane, the protein
CC       forms a sodium-selective channel through which Na(+) ions may pass in
CC       accordance with their electrochemical gradient.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- FUNCTION: Tetrodotoxin-resistant channel that mediates the voltage-
CC       dependent sodium ion permeability of excitable membranes. Assuming
CC       opened or closed conformations in response to the voltage difference
CC       across the membrane, the protein forms a sodium-selective channel
CC       through which sodium ions may pass in accordance with their
CC       electrochemical gradient. Plays a role in neuropathic pain mechanisms.
CC       {ECO:0000256|ARBA:ARBA00025291}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963,
CC         ChEBI:CHEBI:29101; Evidence={ECO:0000256|ARBA:ARBA00036239};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       Nav1.8/SCN10A subfamily. {ECO:0000256|ARBA:ARBA00006764}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   RefSeq; XP_025856775.1; XM_026000990.1.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   CDD; cd13433; Na_channel_gate; 1.
DR   Gene3D; 1.10.287.70; -; 4.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 1.20.5.1190; iswi atpase; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR044564; Na_chnl_inactivation_gate.
DR   InterPro; IPR010526; Na_trans_assoc_dom.
DR   InterPro; IPR043203; VGCC_Ca_Na.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF208; SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM        131..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        161..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        192..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        252..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        376..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        698..720
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        787..807
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        870..893
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1154..1172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1193..1209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1221..1240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1285..1305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1358..1376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1396..1419
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1512..1530
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1542..1561
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1597..1625
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1700..1723
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   DOMAIN          134..409
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          669..899
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          907..1148
FT                   /note="Sodium ion transport-associated"
FT                   /evidence="ECO:0000259|Pfam:PF06512"
FT   DOMAIN          1152..1428
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          1477..1733
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          32..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          449..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          519..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1009..1030
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1070..1090
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1908..1956
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..473
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..488
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..568
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1956 AA;  219974 MW;  18194744569D7BDE CRC64;
     MEFPFGSLET TNFRRFTPES LVEIEKRIAA KQAAKKAKGK HREQKDQEEK PRPQLDLKAC
     NQLPKFYGEL PAELVGEPLE DLDPFYSTHR TFMVLDKGRT ISRFSATRAL WLFSPFNLIR
     RTAIKVSVHS YPLWFSLFIT VTILVNCVGM TQTELPDRIE YVFTVIYTFE ALIKILARGF
     CLNEFAYLRD PWNWLDFSVI TLAYIGEATA LRGISGLRTF RVLRALKTVS VIPGLKVIVG
     ALIHSVRKLA DVTILTVFCL SVFALVGLQL FKGNLKNKCV KNCAALNETG NYSSYGKPDF
     YYNKPGTSDP LLCGNGSDAG HCPKGYLCLK TSDNPDFNYT SFDSFAWAFL SLFRLMTQDS
     WERLYQQTLR ASGKMYMVFF VLVIFLGSFY LVNLILAVVT MAYEEQNQAT IDEIEAKEKT
     FQETLEMLRK EQEVLAALGI DTASLHSYNG SPLPSKNASE RMHRMKPRVS EGSTDDNKSP
     QSDPYNQRRM SFLGLTSGRR RASHGSVFHF RTPCLDTSFP DGVTDDGVFP GDRESHRGSL
     LLGGGTSQQG PLLRSPLPQP SNPGSGHGED GHSTLPTGEL APGGIEVSAF DAGQKKTFLS
     AEYLNEPFPA QRAMSVVSIM TSVLEELEES ERRCPPCLTS FAQKYLIWEC CPTWVKLKTV
     LFGIVTDPFA ELTITLCIVV NTVFMAMEHH GMSSAFEAML QIGNIVFTVF FTAEMVFKII
     AFDPYYYFQK RWNIFDCIIV TVSLIELGAA RKGSLSVLRT FRLLRVFKLA KSWPTLNTLI
     KIIGNSVGAL GNLTIILAII VFVFALVGKQ LLGENYRDNR RNISAPNEEW PRWHMHDFFH
     SFLIVFRILC GEWIENMWAC MEVGQKSVCL ILFLTVMVLG NLVVLNLFIA LLLNSFSADN
     LATPDEDGEV NNLQVALARI QAFGHRTKKA ICNFFTRPCL LPWPKAEPQL VVKLPLSSSK
     AENHIAANAA VGSPRGLPVS RGLRDDHSDF ITNPNIWVSV PIAEGESDLD DLEEDGEEDS
     QSSQQEAILQ GQEQLQVETC EGHMAPRSPG SGMSSEDLAS YVDEKWKDEA AAQAPAEGGD
     DTSSSEGSTV DCLDPEEILR KIPELADDLE EPDDCFTEGC LRHCPCCKVD ISKFPWTVGW
     QVRKTCYRIV EHSWFESFII FMILLSSGSL AFEDYHLDQK PTVKALLEYT DRVFTFIFVL
     EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILQ YSDVASIKAL RTLRALRPLR
     ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG VNFFAGKFGR CINKTNEYFS
     LVPLSIVNNI SDCKYQNHTG SFFWVNVKVN FDNVAMGYLA LLQVATFKGW MDIMYAAVDA
     RDVNLQPKWE DNVYMYLYFV IFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ
     KKYYNAMKKL GSKKPQKPIP RPLNKYQGFV FDIVTKQAFD IVIMVLICLN MITMMVETDE
     QSAEKTKILN KINQFFVAVF TGECVMKMFA LRHYYFTNGW NVFDFIVVVL SIGSLVFSVI
     LTSLENYFSP TLFRVIRLAR IGRILRLIRA AKGIRTLLFA LMMSLPALFN IGLLLFLVMF
     IYSIFGMASF PHVSWEAGID DMFNFQTFAN SMLCLFQITT SAGWDGLLSP ILNTGPPYCD
     PNLPNSNGSR GNCGSPAVGI LFFTTYIIIS FLIVVNMYIA VILENFNVAT QESSEPLSED
     DFDMFYETWE KFDPEATQFI TFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH
     CLDILFAFTK NVLGESGELD SLKANIEEKF MATNVSKTSY EPIATTLRWK QEDISATVIQ
     KAYRSYVLHR SMTISNPPAV PRAEEAVPPP DEAFVEFMVN ENCALPDKSE TASAASFPPS
     YDSVTRGLSD QINMSTSSSM QNEDEGTSNK VTAPGP
//
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