ID A0A3Q7TQZ3_VULVU Unreviewed; 728 AA.
AC A0A3Q7TQZ3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Rho-related BTB domain-containing protein 2 isoform X2 {ECO:0000313|RefSeq:XP_025863707.1, ECO:0000313|RefSeq:XP_025863708.1};
GN Name=RHOBTB2 {ECO:0000313|RefSeq:XP_025863707.1,
GN ECO:0000313|RefSeq:XP_025863708.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025863707.1};
RN [1]
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025863708.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025863708.1};
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025863707.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025863707.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025863707.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025863707.1; XM_026007922.1.
DR RefSeq; XP_025863708.1; XM_026007923.1.
DR Ensembl; ENSVVUT00000008797; ENSVVUP00000006593; ENSVVUG00000005099.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd18531; BACK_RHOBTB2; 1.
DR CDD; cd18356; BTB1_POZ_RHOBTB2; 1.
DR CDD; cd18359; BTB2_POZ_RHOBTB2; 1.
DR CDD; cd01873; RhoBTB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR PANTHER; PTHR24072:SF137; RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00651; BTB; 3.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00225; BTB; 2.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54695; POZ domain; 2.
DR PROSITE; PS50097; BTB; 2.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 266..443
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 501..568
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 304..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 82781 MW; 9A3405A1B1FD6AB4 CRC64;
MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNATL TQYQLLATHV PTVWAIDQYR
VCQEVLERSR DVVDDVSVSL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLHHVKT
MWYPEIKHFC PRAPVILVGC QLDLRYADLE AVNRARRPLA RPIKPNEILP PEKGREVAKE
LGIPYYETSV VAQFGIKDVF DNAIRAALIS RRHLQFWKSH LRNVQRPLLQ APFLPPKPPP
PIIVVPDPPS SSEECPAHLL EDPLCADVIL VLQERVRIFA HKIYLSTSSS KFYDLFLMDL
SEGELGGPSG PGGPRPEDHR GHPDHHHHHH HHHHHGRDFL LRAASFDVCE SVEEGGGSGP
AGLRASTSDG ILRGNGTGYL PGRGRVLSSW SRAFVSIQEE MAEDPLTYKS RLMVVVKMDN
SIQPGPFRAV LKYLYTGELD ENERDLMHIA HIAELLEVFD LRMMVANILN NEAFMNQEIT
KAFHVRRTNR VKECLAKGTF SDVTFILDDG TISAHKPLLI SSCDWMAAMF GGPFVESSTR
EVVFPYTSKS CMRAVLEYLY TGMFTSSPDL DDMKLIILAN RLCLPHLVAL TEQYTVTGLM
EATQMMVDID GDVLVFLELA QFHCAYQLAD WCLHHICTNY NNVCRKFPRD MKAMSPENQE
YFEKHRWPPV WYLKEEDHYQ RARKEREKED YLHLKRQPKR RWLFWNSPSS PSSSAASSSS
PSSSSAVV
//
