ID A0A3Q7TR75_VULVU Unreviewed; 451 AA.
AC A0A3Q7TR75;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083, ECO:0000256|PIRNR:PIRNR007858};
GN Name=ORC4 {ECO:0000313|RefSeq:XP_025863787.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025863787.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025863787.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025863787.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025863787.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. {ECO:0000256|PIRNR:PIRNR007858}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR007858}.
CC -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000256|ARBA:ARBA00005334,
CC ECO:0000256|PIRNR:PIRNR007858}.
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DR RefSeq; XP_025863787.1; XM_026008002.1.
DR AlphaFoldDB; A0A3Q7TR75; -.
DR KEGG; vvp:112926862; -.
DR OrthoDB; 230201at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR PIRSF; PIRSF007858; ORC4; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR007858};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR007858};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR007858};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 68..211
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 451 AA; 52454 MW; 7D6953241E550A37 CRC64;
MFHGFQCIKM SSRKSKSNNV IHAEYLSQVQ RILRERFCHQ SPQSNLFGVQ VQYKHLIELL
KRTAIYGESN SVLIIGPRGS GKTMLINHAL KELMEVEEVS ENVLQVHLNG LLQINDKIAL
KEITRQLNLE NVVGDKVFGS FAENLSFLLE ALKKGDRSSS CPVIFILDEF DLFTHHKNQT
LLYNLFDISQ SAQTPLAVIG LTCRLDILEL LEKRVKSRFS HRQIHLMNSF GFPQYLKIFK
EQLSLPAEFP DKLFSEKWNE NVQCLMEDRS VREVLQKHFN VSKNLRSLHM LLHSDRYEML
ALNRVTTSHP FMTAADLMEA NQLCSMDSKA NIVHGLSVLE ICLIIAMKHL NDIYEEEPFN
FQMVYNEFQK FVQRKAHSVY NFEKPVVMKA FEHLQQLELI KPMERTSVNT QREYQLMKLL
LDNTQIMNAL QKYPNCPTDV RQWATSSLSW L
//
