ID A0A3Q7TRL1_VULVU Unreviewed; 555 AA.
AC A0A3Q7TRL1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Heterochromatin protein 1-binding protein 3 {ECO:0000256|ARBA:ARBA00019297};
GN Name=HP1BP3 {ECO:0000313|RefSeq:XP_025867871.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025867871.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025867871.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025867871.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025867871.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_025867871.1; XM_026012086.1.
DR AlphaFoldDB; A0A3Q7TRL1; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR15832:SF1; HETEROCHROMATIN PROTEIN 1-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR15832; SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG; 1.
DR Pfam; PF00538; Linker_histone; 3.
DR SMART; SM00526; H15; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51504; H15; 3.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 159..234
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 257..332
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 339..415
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT REGION 29..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 61508 MW; 4EFDFE558F4A3E9E CRC64;
MATDTSQGEF VHPKALPLIV GAQLIHADKL GEKVEDSTMP IRRTVNSTRE TPPKSKLAEG
EEEKPDQKPD ISSEESVSTV EEQENETPPA TSSETEQPKG EPENEEKEEN KSSEETKKDE
KDQSKEKEKK VKKTIPSWAT LSASQLARAQ KQTPMASSPR PKMDAILTEA IKACFQKSGA
SVVAIRKYII HKYPSLELER RGYLLKQALK RELNRGVIKQ VKGKGASGSF IVVQKSRKTP
QKSRNRKNRS AAVDPEPQVK LEDILPLAFT RLCEPKEASY SLIRKYVSQY YPKLRVDIRP
QLLKNALQRA VERGQLEQIT GKGASGTFQL KKSGEKPLLG GSLMEYAILS AIAAMNEPKT
CSTTALKKYV LENHPGTNSN YQMHLLKKTL QKCEKNGWME QISGKGFSGT FQLCFPYYPS
PGVLFPKKEL DDSRDEDEEE DDSSEEDSDD EEPPPKRRLQ KKTPAKSSVK AASVKQRGSK
PAPKVPAAQR GKARPLPKKA PPKAKTPAKK ARPSSSVIKK PSGGSSKKPA ANVRKEVKLP
SKGKATMKKS FKAKK
//
