ID A0A3Q7TT05_VULVU Unreviewed; 1713 AA.
AC A0A3Q7TT05;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Alpha-protein kinase 3 {ECO:0000313|RefSeq:XP_025858385.1};
GN Name=ALPK3 {ECO:0000313|RefSeq:XP_025858385.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025858385.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025858385.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025858385.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025858385.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Alpha-type
CC protein kinase family. ALPK subfamily. {ECO:0000256|ARBA:ARBA00008651}.
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DR RefSeq; XP_025858385.1; XM_026002600.1.
DR STRING; 9627.ENSVVUP00000008134; -.
DR KEGG; vvp:112922894; -.
DR OrthoDB; 5321836at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR47091; ALPHA-PROTEIN KINASE 2-RELATED; 1.
DR PANTHER; PTHR47091:SF1; ALPHA-PROTEIN KINASE 3; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_025858385.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 101..197
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1282..1370
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1398..1633
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1258..1275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1713 AA; 181399 MW; 5EE5C5D173325149 CRC64;
MEENTRHVQR SSTETRGFVS VADQLQCKAR ARGPRPGERG GPPGGDGEDD GPVWIPSPAS
RSYLLSVRPE TSLSSNRFSH PSSGRSTFCS IIAQLTEETQ PLFETTLKSR AVSEDSDARF
TCIVTGYPEP EVTWYKDDIE LDRYCGLPKY EITHQGNRHT LQLYRCQEED AAIYQASARN
TKGIVSCSGV LEVGTMTEYK IHQRWFAKLK RKAAAKMREI EQNWKPRKEV VGDVDTLRKL
SPDRFQRKRR LSGDEVSAPL APTEEAEAET PAAWQEDETE TGQHPGLGLI NSFAPGDVTT
NGEAAPENGE DGEHGLLTYI CEAMERGPQR PPKKESGAKK KKKDEESKQG LRKPELEKAA
RSHHSSENRA PSSDQPDSCG TQGPTDMEQV QAWPRGRAAR GPGSSGVDST RKPASAVGTQ
DQAQKAPAPG PVPGPDQQVY FSLKDMYLES TRAGRPKGEE GSQAPSGRAP GEMSSGKVPS
EAGGERSPVA PGQPMSSAPQ PTRPFNRKRF APPKPKGEPT ANSKPDASLS QASEPGVQSL
GKAPSQASAQ VPTPPARRRH TTRDSPLLGQ AGHRTSGEVL ESQATLASTV LASNSADTVS
AGCSNSRGQG VIEPMDTDTQ EDRRTSADQK PGGNKNTEAD GKTQVDRRTQ GGRTQTTQRT
QVDRKTQVDI VPKESESPAS ARSPQENVVA QGRAVTQAER TQTDERMQED GRIQEDRGTR
SEGSIATKGQ SEKGSVASLS PQSRVPERPP AESPQSPQTI ECFEQTPEGS SVPEESGFVL
TSEEAAAPVP GSSLTAMLDA PAGGPTPPGP QPPRRGSGQQ GGARSRVSEG SGLVEDKPED
GLIPCPKEEQ LGAVLSMDLG GCPPASWSPE GPILPSPHGP GLPKSSREAL PSSLPSQHMS
AATFLPSGDQ AVLRSVPPPH LGPGTPTQSH LSATTAGDGE GACAEGPDVE GRSPGPRSCD
PGLIDSLKNY LLLLLKLSST ETGGGGAESQ ERAAPGAPGP SPTLVPNVEV AGLSPRTSRR
ILERVENNHL VQSAQSLLLS PCTSRRLTGL LDREVQAGRQ ALAAAGGPGP CTLTVPAIVV
GEEEGPGLAS GGSSEGEAEA EASPEGPGFP GISQEGSVGG PLGEAGGQTA SGQGPVSADR
RAQDSFQQEE APGEALIGLP AATPEELALG ARRKRFLPKV RAAGDGEAAK AEERESPTVS
PRGPRKGLAP GSPGTPGREK RSPTQGRKAG MLEVPRAEEE PAAGDLGSSP KAGSVDAELA
SDEGKQDTSA KPRKAKDLLK APQVIRKIRV EQFPDASGSL KLWCQFFNIL SDSVLTWAKD
QRPVGEVGRS AGDEGPAALA IVQASPVDCG MYRCTIHNEH GSASTDFCLS PEVLSGFISR
EEGEVGEEIE MTPMVFAKGL ADSGCWGDKL FGRLVSEELR GSGHGYGLRK ASQAKVIYGL
EPIFESGRTC IIKVSSLLVF GPSSETSLLG RNYDVTIQGC KIQNMSREYC KIFAAEAQAA
PGFGEVPEIL PLYLIYRPAN NIPYATLEED LGKPLQPYCS REWGCAVAPE TSSNSEVRQK
CQTFQHWLYL WTNGSFLVTD LAGVDWKMTD VQIATKLRGY QGLKESCFPA LLDQFASSHQ
CNTFCEMLGL KPLKGPEAAH PQAKAKGSKS PSTGRKGGQL SPQPQKKGLP SPQGTRKSTP
SSKATPQASE ALATQLLGQP PTQEGGPKAQ GLR
//
