ID A0A3Q7TT14_VULVU Unreviewed; 2576 AA.
AC A0A3Q7TT14;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Nuclear receptor corepressor 2 isoform X5 {ECO:0000313|RefSeq:XP_025872953.1};
GN Name=NCOR2 {ECO:0000313|RefSeq:XP_025872953.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025872953.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025872953.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025872953.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025872953.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR RefSeq; XP_025872953.1; XM_026017168.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Receptor {ECO:0000313|RefSeq:XP_025872953.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 427..478
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 608..659
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 611..655
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 612..659
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1458..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1525..1626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1785..1888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1982..2054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2086..2130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2167..2186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2237..2302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2310..2329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2449..2561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..819
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1016
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1200..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1602..1626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1785..1808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1809..1834
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1835..1888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2168..2186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2315..2329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2487..2501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2576 AA; 280622 MW; 0D1B79D5227468D9 CRC64;
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARPHTDVGLL EYQHHPRDYT SHLSPGSIIQ
PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM EFIESKRPRL ELLPDPLLRP
SPLLAAGQPG ASEDLSKDRS LAGKLEPVSP PSPPHADPEL ELVPPRLSKE ELIQNMDRVD
REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA
AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG
LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM
KVYKDRQVMN MWSEQEKETF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK
SLVRRSYRRR GKSQQQQQQQ QQQQQQQQQM PRSSQEEKEE KEKDKEAEKE EEKPDVENDK
EELNKEKTDD TSGEDNDEKE AVASKGRKTA NSQGRRKGRI TRSMANEANS EEAITPQQSA
ELASMEMNES SRWTEEEMET AKKGLLEHGR NWSAIARMVG SKTVSQCKNF YFNYKKRQNL
DEILQQHKLK MEKERNARRK KKKAPAAASE EAAFPPVVED EEMEASGASG NEEEMAEEAE
ALHASGNEVP RGECSGPATV NNSSDTESIP SPRTEAAKDT GQNGPKPPPG PGTDVLPPEP
PTPPPEDALV SSEPGPAPET TNPPTPPPAP ASPTAPPPVV PKEEKEEEDA AAPLVAEEEE
QKPPVAQEMA VDMGKTEEPG EASPAEPIKS ECKEEATEEG PDKGKGGSEP SAEAEATPEG
ALKVEKKEGG GPGGKAPTAK GAGAPQDSDS SATCSADEVD EPEGGDKNRL LSPRPSLLTS
TSDARASASP QKPLDLKQLK QRAAAIPPIV TKVHEPPRED AAPPALPPPQ PLQPENDTPQ
QPSSSPRGKS RSPVPPADKE EKPVFFPAFA PEGQKLPTEA PCWTSGLPFP VPPREVIKAS
PHTPDPSAFS YAPPGHPLPL GLHDSVRPVL PRPPTISNPP PLISSTKHPS VLERQMSAIS
QGMSVQLHVP YSEHAKAPVG PITMGLPLAM DPKKLAPFSG VKQEQLSPRG QAGPPESLGV
PTAQETSVLR GTSLGSVPGG SITKGIPSTR VPPESPISYR GSITHGTPAD VLYKGTITRI
IGEDSPSRLD RSREDSLPKG HVIYEGKKGH VLSYEGGMSV SQCSKEDGRS SSGPPHETAA
PKRTYDMMEG RVSRAISSAS IEGLMGRAIP PERHSPHHLK EQHHIRGSIT QGIPRSYVEA
QEDYLRREAK LLKREGTPPP PPPPPRDLAE AYKARPLEAL GPLKLKPAHE GMVATVKEAG
RSIHEIPREE LRRTPELPLA PRPLKEGSIT QGTPLKYDTG TSSAGSKKHD VRSIIGSPGR
TFPPVHPLDV MADARALERA CYEESLKSRP GAAGSSGGSI TRGAPVIVPE LGKPRQSPLT
YEEHGAPFAG HLPRGSPVTT REPTPRLQEG SLSSSKASQD RKLTSTPREI AKSPHSAVPE
HHPHPISPYE HLLRGVSGVD LYRGHIPLAF DPTSIPRGIP LDAAAAYYLP RHLAPNPTYP
HLYPPYLIRG YPDTAALENR QTIINDYITS QQMHHNAATA MAQRADMLRG LSPRESSLAL
NYAAGPRGII DLSQVPHLPV LVPPTPGTPA TAMDRLAYLP TAPQHFSSRL SSSPLSPGGP
THLTKPSATS SSERERERDR DREREREREK SILTSTTTVE HAPIWRPGTE QSSGSSGSGG
GGSSSGGSRP ASHSHSHQHS PISPRTQDAI QQRPSVLHNT GMKGIITSVE PSTPTVLRWA
RSTSTSSPVR PAATFPPTTH CPLGGTLDGV YPTLMEPVLP PKEAPRVARP ERPRADAGHA
FLAKPQARVG LEPASPPSKG SEPRPLAPPS SSHSAIARTP AKSLAPHHAG PDQPAPPTSA
TDLHREKTQS KPFSIQELEL RSLGKTTLTA ATFIDAIIMR QIAHDKGPRE GGSLANDSPR
DGYHGGSYSP DGVEPISPVS SPSLTHDKGL PKHLEELDKS HLEGDLRHKQ PGPGKLSGEA
AHLSHLRPLP ESQSSSSPLL QTTPGVKGHQ RVVTLAQHIS EVITQDYTRH HPQQLNAPLP
APLYSFPGAS CPVLDLRRPP SDLYLPPPDH GAPARGSPHS EGGKRSPEPS KMSALGSSED
AIEPVSPPEG LAEPGHPRST MYPLLYRDGE QTETSRMGSK SPGNTSQPPA FFSKLTESNS
AMVKSKKQEI NKKLNTHNRN EPEYNIGQPG TEIFNMPAIT GAGLMTCRSQ AVQEHASTNM
GLEAIIRKAL MGKYDQWEEP PLSANAFNPL NASASLPAAI PITAADGRSE HALTSPGGGG
KAKVSGRPSS RKAKSPAPGL ASGDRPPSVS SVHSEGDCNR RTPLTNRVWE DRPSSAGSTP
FPYNPLIMRL QAGVMASPPP PGLPAGSGPL AGPHHAWDEE PKPLLCSQYE TLSDSE
//
