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Database: UniProt
Entry: A0A3Q7TW96_VULVU
LinkDB: A0A3Q7TW96_VULVU
Original site: A0A3Q7TW96_VULVU 
ID   A0A3Q7TW96_VULVU        Unreviewed;       655 AA.
AC   A0A3Q7TW96;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Plasma kallikrein isoform X1 {ECO:0000313|RefSeq:XP_025874073.1};
GN   Name=KLKB1 {ECO:0000313|RefSeq:XP_025874073.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025874073.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025874073.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025874073.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025874073.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   RefSeq; XP_025874073.1; XM_026018288.1.
DR   AlphaFoldDB; A0A3Q7TW96; -.
DR   KEGG; vvp:112934777; -.
DR   OrthoDB; 5292922at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd01100; APPLE_Factor_XI_like; 4.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR   InterPro; IPR000177; Apple.
DR   InterPro; IPR003609; Pan_app.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24253:SF64; PLASMA KALLIKREIN; 1.
DR   PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR   Pfam; PF00024; PAN_1; 4.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00005; APPLEDOMAIN.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00223; APPLE; 4.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS00495; APPLE; 1.
DR   PROSITE; PS50948; PAN; 3.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   4: Predicted;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          130..213
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          220..303
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          311..394
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          410..646
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   655 AA;  73133 MW;  1A8942AED6941863 CRC64;
     MINMICNQQG YVCVAFSSRM ISFRQAAYFT CFFATVSCGC LTQLYKNTFF KGGDLTAMYT
     PNVHHCQMMC TFHPRCLLFS FLPESSTNDV NKRFGCFLKD SVTETLPRMS WTSAISGHSL
     KQCGHQISAC HRDIHKGIDM RGVNFNVSKV KSVEECQKKC TNSIHCQFFT YATETFYNAE
     YRNSCLLKNG PEGTPSSIKV LADVVSGFSL KSCALSEIGC HMNIFQHLAF SDVDVARVVT
     PDAFVCQTIC TYHPNCLFFT FYTKAWHLEP QRNVCFLKTS KSGTPSSPTS QENAMSGYSL
     LTCKKALPEP CHSKIYSGVD FEGEELNVTF AEGVNACQET CTKMIRCQFF TYSLRPEDCR
     GEKCKCSLRL SLDGSPTGMT YGTRVSSGYS LRLCKSGDSS VCTTKTSTRI VGGTNSSWGE
     WPWQVSLQVK LRAQSHLCGG SIIGHQWVLT AAHCFDELSL PDVWRIYSGI LNLSEITKET
     PFSQIKEIII HQNYKITDGG SYDIALIKLE APLNYTEFQK PICLPSKDDT NTTYTNCWVT
     GWGFTKERGE IQNTLQKANI PLVPNEECQK KYRDYEVNKQ MICAGYKEGG KDACKGDSGG
     PLVCKHNGNW HLVGITSWGE GCGRREQPGV YTKVAEYVDW ILEKTQVGDG HTGLG
//
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