ID A0A3Q7TW96_VULVU Unreviewed; 655 AA.
AC A0A3Q7TW96;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Plasma kallikrein isoform X1 {ECO:0000313|RefSeq:XP_025874073.1};
GN Name=KLKB1 {ECO:0000313|RefSeq:XP_025874073.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025874073.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025874073.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025874073.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025874073.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_025874073.1; XM_026018288.1.
DR AlphaFoldDB; A0A3Q7TW96; -.
DR KEGG; vvp:112934777; -.
DR OrthoDB; 5292922at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd01100; APPLE_Factor_XI_like; 4.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24253:SF64; PLASMA KALLIKREIN; 1.
DR PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR Pfam; PF00024; PAN_1; 4.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00005; APPLEDOMAIN.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00223; APPLE; 4.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00495; APPLE; 1.
DR PROSITE; PS50948; PAN; 3.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..213
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 220..303
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 311..394
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 410..646
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 655 AA; 73133 MW; 1A8942AED6941863 CRC64;
MINMICNQQG YVCVAFSSRM ISFRQAAYFT CFFATVSCGC LTQLYKNTFF KGGDLTAMYT
PNVHHCQMMC TFHPRCLLFS FLPESSTNDV NKRFGCFLKD SVTETLPRMS WTSAISGHSL
KQCGHQISAC HRDIHKGIDM RGVNFNVSKV KSVEECQKKC TNSIHCQFFT YATETFYNAE
YRNSCLLKNG PEGTPSSIKV LADVVSGFSL KSCALSEIGC HMNIFQHLAF SDVDVARVVT
PDAFVCQTIC TYHPNCLFFT FYTKAWHLEP QRNVCFLKTS KSGTPSSPTS QENAMSGYSL
LTCKKALPEP CHSKIYSGVD FEGEELNVTF AEGVNACQET CTKMIRCQFF TYSLRPEDCR
GEKCKCSLRL SLDGSPTGMT YGTRVSSGYS LRLCKSGDSS VCTTKTSTRI VGGTNSSWGE
WPWQVSLQVK LRAQSHLCGG SIIGHQWVLT AAHCFDELSL PDVWRIYSGI LNLSEITKET
PFSQIKEIII HQNYKITDGG SYDIALIKLE APLNYTEFQK PICLPSKDDT NTTYTNCWVT
GWGFTKERGE IQNTLQKANI PLVPNEECQK KYRDYEVNKQ MICAGYKEGG KDACKGDSGG
PLVCKHNGNW HLVGITSWGE GCGRREQPGV YTKVAEYVDW ILEKTQVGDG HTGLG
//