ID A0A3Q7TZL1_VULVU Unreviewed; 532 AA.
AC A0A3Q7TZL1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Interferon regulatory factor 5 {ECO:0000313|RefSeq:XP_025866582.1};
GN Name=IRF5 {ECO:0000313|RefSeq:XP_025866582.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025866582.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025866582.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025866582.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025866582.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025866582.1; XM_026010797.1.
DR AlphaFoldDB; A0A3Q7TZL1; -.
DR STRING; 9627.ENSVVUP00000014922; -.
DR KEGG; vvp:112928914; -.
DR OrthoDB; 3740806at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF10; INTERFERON REGULATORY FACTOR 5; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 27..135
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..165
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 59543 MW; 29F66813F3A29C4C CRC64;
MRRLWVSPTD PLAMNQPAPR APPPPRRVRL KPWLVAQVNS CQYPGLQWVN GERKFFCIPW
RHATRHGPSQ EGDNTIFKAW AKETGKYTEG VDEADPAKWK ANLRCALNKS RDFRLIYDGP
RDMPPQPYKI YEVCSNGSAP AESQPSEDYT FGAGEEEEEE EEDMSSGPFL AASACTDVLQ
RMLPSLSITE AVQPGPPMAP YSLPKEDVKW PPTLQPPVVL GPPAPDPSLL GPTPGNPAGF
GELLPEVLPS LQPGPLAASL PPTGEQLLPD LLISPHMLPL TDLEIKFQYR GRPPRALTIS
NPQGCRLFYS QLEPTQDQVE LFGPVSLEQV RFPSPEDIPS DKQRFYTNQL LDVLDRGLIL
QLQGQDLYAI RLCQCKVFWS GPCASAHGSH PNPIQREVKT KLFSLEHFLN ELILFQKGQT
NTPPPFEIFF CFGEEWPDRK PREKKLITVQ VVPVAARLLL EMFSGELSWS ADSIRLQISN
PDLKDRMVEQ FKELHHLWQS QQRLQPVAQA PAVAGLSAGQ GAWPMHSVGM QQ
//
