ID A0A3Q7U070_VULVU Unreviewed; 864 AA.
AC A0A3Q7U070;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Disks large homolog 2 isoform X6 {ECO:0000313|RefSeq:XP_025870986.1};
GN Name=DLG2 {ECO:0000313|RefSeq:XP_025870986.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025870986.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025870986.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025870986.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025870986.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025870986.1; XM_026015201.1.
DR AlphaFoldDB; A0A3Q7U070; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12032; SH3_DLG2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR035759; DLG2_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 65..152
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 160..247
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 401..482
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 516..586
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 674..849
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 628..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 96767 MW; D525B245045F3C61 CRC64;
MQRPSASRAE NYQLLWDTIA SLKQCEQAMQ HAFIPASPAP IIVNTDTLDT IPYVNGTEIE
YEFEEITLER GNSGLGFSIA GGTDNPHIGD DPGIFITKII PGGAAAEDGR LRVNDCILRV
NEVDVSEVSH SKAVEALKEA GSIVRLYVRR RRPILETVVE IKLFKGPKGL GFSIAGGVGN
QHIPGDNSIY VTKIIDGGAA QKDGRLQVGD RLLMVNNYSL EEVTHEEAVA ILKNTSDVVY
LKVGKPTTIY MTDPYGPPDI THSYSPPMEN HLLSGNNGTL EYKTSLPPIS PGRYSPIPKH
MLVEDDYTRP PEPVYSTVNK LCDKPASPRH YSPVECDKSF LLSAPYPHYH LGLLPDSEMT
RETEHIRSRE WGLSHSQHST ATRQPSVTLQ RAISLEGEPR KVVLHKGSTG LGFNIVGGED
GEGIFVSFIL AGGPADLSGE LQRGDQILSV NGIDLRGASH EQAAAALKGA GQTVTIIAQY
QPEDYARFEA KIHDLREQMM NHSMSSGSGS LRTNQKRSLY VRAMFDYDKS KDSGLPSQGL
SFKYGDILHV INASDDEWWQ ARRVTLEGDS EEMGVIPSKR RVERKERARL KTVKFNAKPG
VIDSKGSFND KRKKSFIFSR KFPFYKNKEQ SEQETSDPEQ HVSSNASDSE SSYRGQEDFI
LSYEPVTRQE INYTRPVIIL GPMKDRINDD LISEFPDKFG SCVPHTTRPK RDYEVDGRDY
HFVISREQME KDIQEHKFIE AGQYNDNLYG TSVQSVRFVA ERGKHCILDV SGNAIKRLQV
AQLYPIAIFI KPKSLEPLME MNKRLTEEQA KKTYDRAIKL EQEFGEYFTA IVQGDTLEDI
YNQCKLVIEE QSGPFIWIPS KEKL
//
