ID A0A3Q7U0W4_VULVU Unreviewed; 742 AA.
AC A0A3Q7U0W4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Polyserase-2 isoform X2 {ECO:0000313|RefSeq:XP_025867007.1};
GN Name=PRSS36 {ECO:0000313|RefSeq:XP_025867007.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025867007.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025867007.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025867007.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025867007.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025867007.1; XM_026011222.1.
DR AlphaFoldDB; A0A3Q7U0W4; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 3.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24253:SF144; BRAIN-SPECIFIC SERINE PROTEASE 4; 1.
DR PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR Pfam; PF00089; Trypsin; 3.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 3.
DR PROSITE; PS50240; TRYPSIN_DOM; 3.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..742
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018766442"
FT DOMAIN 47..291
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 290..555
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 601..742
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 25..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 79743 MW; EE6D465F0E90E058 CRC64;
MSHHLLLPLV ILAISPIPGA FQNSALSSTQ EEPEDLDCGR PEPSARILGG SDAQPGSWPW
QVSLHQSGSH ICGGSLIAPS WVLSAAHCFV TNGTLEPATD WSVLLGAHSQ AAAPDGAHVR
AVAAILVPRN YSGVDRGADL ALLRLASPAR LGPAVRPVCL PRASHRFAHG ATCWATGWGD
IQEADPLPLP WVLQEVELRL LGEAACQCLY SRPGPFNLTF QLLPGMLCAG YPEGRRDTCQ
GDSGGPLVCE EGGRWFQAGV TSFGFGCGRR NRPGIFTAVA PYEAWIREQV IGSEPGPAFP
TQSWEPQSGA WEPTDQNCSI ALPECGKAPR PGAWPWEAQV MVPGSRPCHG ALVSESWVLA
PASCFLDPIN SDGPPRDLDT WRVLLPSRPR AELVARLVPH DNASWDDASD LALLQLRAPV
NLSTAPRPVC LPHPEHYFLP GSRCRLARWG RGEPAPGPNA QLEAELLGGW WCHCLYGRQG
ASVPPPGDPP RALCPAYQEE EEAGGCWNYS HRSLLCQEEG TWFLAGISDF SSGCLRPRVF
HPLQTHGPWI SHVTRGAYLE DQLTWDWGSE GEETDTQTCP PHTEHGACGL RPEPAVVGVL
WPWLAEVHVA GDRVCIGILV APGWVLAATH CVLRPGSTTV PYIEVYLGRA GASPLPQGHQ
VSRVVTSIRL PRHLGLRPPL ALLELSSRVE PSPSALPICL HPGGIPLGAS CWVLGWKDPR
DRGHPAPWDS LCSVFGGSGG QM
//
