ID A0A3Q7U214_VULVU Unreviewed; 1563 AA.
AC A0A3Q7U214;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 1 isoform X3 {ECO:0000313|RefSeq:XP_025871776.1};
GN Name=LTBP1 {ECO:0000313|RefSeq:XP_025871776.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025871776.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025871776.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025871776.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025871776.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_025871776.1; XM_026015991.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 12.
DR Gene3D; 2.10.25.10; Laminin; 18.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 15.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 18.
DR SMART; SM00179; EGF_CA; 16.
DR SUPFAM; SSF57196; EGF/Laminin; 8.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 11.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 45..77
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 243..275
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 401..446
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 470..507
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 521..573
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 759..800
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 882..922
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 923..963
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 964..1004
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1005..1045
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1046..1087
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1088..1125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1189..1243
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1366..1419
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1504..1548
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 77..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 49..59
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 67..76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 247..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 265..274
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1563 AA; 170800 MW; 1220FAF099547974 CRC64;
MVPGTAISLV WTLLSQTQIR FKRVNVCGGQ CCHGWSKAPG SQRCTKPSCV PPCQNGGMCL
RPQLCVCKPG TKGKACESTA AQDTSSPGFG GQSPGAASSW VPPEQAAKHT SLKKADSLPR
ISPVAQMTLT LKPKPSVGLS QQIHSHIWRV TPLSSQNVMI HHGQTQEYVL KPKYFAAQKV
ISGEQSTEVS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK GNTTTLISEN GHAADTLTAT
NFRVVICHLP CMNGGQCSSR DKCQCPPNFT GKLCQIPVHG ASVPKLYQHS QQSGKALGTH
VVHSTHTLPL TMTSQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRIDGP TGQKTKEAQP
SQSQISYQGL PVQKTQTVHS TYSHQQVIPH VYPVAAKTQL GRCFQETIGS QCGKALPGLS
KQEDCCGTVG TSWGFNKCQK CPKKPSYHGY NQMMECLQGY KRVNNTFCQD INECQLQGVC
PNGECLNTMG SYRCTCKMGF GPDPTFSSCV PDTPVISEEK GPCYRLVSSG RQCMHPLSVH
LTKQLCCCSV GKAWGPHCEK CPLPGTAAFK EICPGGMGYT VSGVHRRRPI HHHVGKGPVF
VKPKNTQPVA KSTHPPPLPA KEEPVEALTF SREHGPGVAE PEVATAPPEK EIPSLDQEKT
KLEPGQPQLS PGISTIHLHP QFPVVIEKTS PPVPVEIAPE ASTSSASQVI APTQVTEINE
CTVNPDICGA GHCINLPVRY TCICYEGYKF SEQQRKCVDI DECTQVQQLC SQGRCENTEG
SFLCICPAGF MASEEGTNCI DVDECLRPDV CGEGHCINTV GAFRCEYCDS GYRMTRGGRC
EDIDECLTPS TCPDEQCVNS PGSYQCVPCT EGFRGWNGQC LDVDECLEPQ VCTNGTCSNL
EGSYMCSCHK GYSPTPDHKH CKDIDECQQG NLCINGQCKN TEGSFRCTCG QGYQLSAAKD
QCEDIDECQH HHLCSNGQCR NTEGSFLCVC DRGYRASALG DHCEDINECL EDNSVCQGGD
CINTEGSYDC TCPDGFQLND NKGCQDINEC ERPGRCGPHG ECLNTDGSFH CVCEQGFSIS
ADGHTCEDID ECVNNTICDS HGFCDNTAGS FRCLCYQGFQ APQDGQGCVD VNECELLSGV
CGEAFCENVE GSFLCVCADE NQEYSPMTGQ CRSRASGDLD EDQPKEEKKE CYYNLNDASL
CDNVLAPNVT KQECCCTSGA GWGDNCEIFP CPVVGTAEFT EMCPRGKGFV PTGESSYDTS
GENYKDADEC MLFGQEICKN GFCLNTQPGY ECYCKQGTYY DPVKLQCFDM DECQDPNSCI
DGQCVNTEGS YNCFCTHPMV LDASEKRCIR PTESHEQIEE TDVYQDLCWE HLSDEYVCSR
PLVGKQTTYT ECCCLYGEAW GMQCALCPMK DSDDYAQLCN IPVTGRRRPY GRDALVDFNE
QYAPEADPYF IQDRFLNSFE ELQAEECGIL NGCENGRCVR VQEGYTCDCF DGYHLDMAKM
TCVDVNECDE LNNRMSLCKN AKCINTEGSY KCVCLPGYVP SDKPNYCTPL NTALNLEKDG
DLE
//
