ID A0A3Q7U4D7_VULVU Unreviewed; 565 AA.
AC A0A3Q7U4D7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Regulator of G-protein signaling 14 isoform X1 {ECO:0000313|RefSeq:XP_025862140.1};
GN Name=RGS14 {ECO:0000313|RefSeq:XP_025862140.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025862140.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025862140.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025862140.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025862140.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025862140.1; XM_026006355.1.
DR AlphaFoldDB; A0A3Q7U4D7; -.
DR STRING; 9627.ENSVVUP00000000040; -.
DR Ensembl; ENSVVUT00000000045; ENSVVUP00000000041; ENSVVUG00000000024.
DR KEGG; vvp:112925539; -.
DR OMA; SQGCLPR; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17137; RBD1_RGS14; 1.
DR CDD; cd08743; RGS_RGS14; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR046992; RBD1_RGS14.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037881; RGS14_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF2; REGULATOR OF G-PROTEIN SIGNALING 14; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 67..184
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 300..371
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 373..443
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 19..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 61158 MW; 0A9E168F4D951732 CRC64;
MPGKPKHLGV PNGRMVLAVS DGELSSTAGP QGQGESRGSS LSIHSLPSGP SSPFPTEEQP
VASWGLSFER LLQDPLGLAY FTEFLKKEFS AENVTFWKAC ERFQQIPASD TQQLAQEARH
IYEEFLSSQA LSPVNIDRQA WLGEEVLAEP RPDMFRAQQL QIFNLMKFDS YARFVKSPLY
RECLLAEAEG RPLREPGSSS PGSPDSTRKK PKLKSGKSLP LGVEELGHLP SAEGSGGRPL
RKSFRKELAG GAPLRRESQG SLNSSASLDL GFLAFVNSKS ESHRKSLGST EGESESRPGK
YCCVYLPDGT ASLALARPGL TIRAMLAGIC EKRGLSLPDI KVYLVGNEQK ALVLDQDCTV
LADQEVRLEN RITFELELVA QERVVRISAK STKRLQDALQ PILAKHGLSP QEVALCLPGE
KQPLDLGKLV SSVAAQRLVL NTLPGVKTPQ IGDIPQCFSQ GSQPRTRNKA THPPPLSLNS
LAEGPGSSTG KRQTCDIEGL VELLNRVQSS GAHDQRGLLC KEDLVLPEFL QLPAQGPNSQ
EAPPQTESEV QPKGDTSDST AHSAL
//