ID A0A3Q7U7J2_VULVU Unreviewed; 4025 AA.
AC A0A3Q7U7J2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ankyrin-2 {ECO:0000313|RefSeq:XP_025869267.1};
GN Name=ANK2 {ECO:0000313|RefSeq:XP_025869267.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025869267.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025869267.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025869267.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025869267.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_025869267.1; XM_026013482.1.
DR STRING; 9627.ENSVVUP00000010383; -.
DR KEGG; vvp:112931022; -.
DR OrthoDB; 5474900at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 144..176
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 239..271
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 272..304
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 305..337
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 338..370
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 371..403
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 404..436
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 437..469
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 470..502
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 503..535
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 536..568
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 569..601
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 602..634
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 635..667
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 668..700
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 701..733
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 734..766
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 767..799
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 979..1134
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1136..1282
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 3546..3630
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1435..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1625..2026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2058..2126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2170..2461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2488..2999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3045..3079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3112..3325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3345..3436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3665..3689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3721..3742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3754..3840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3998..4025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1625..1658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1659..1673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1687..1714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1741..1780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1794..1833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1841..1879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1983..2023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2058..2100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2109..2126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2216..2230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2245..2261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2278..2301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2322..2380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2498..2532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2543..2601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2609..2624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2632..2647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2672..2699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2700..2722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2758..2779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2780..2810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2814..2831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2862..2884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2905..2965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2966..2980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2981..2999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3048..3079
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3171..3191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3270..3284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3345..3360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3419..3435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3665..3688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3754..3775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3801..3819
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4025 AA; 442669 MW; 40268C3396D8721D CRC64;
MAHAAASIKK VREAELDEKE KTLERERKKQ RKIPRERMER KRKSDSNASF LRAARAGNLD
KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG RGSSVDSATK KGNTALHIAS
LAGQAEVVKV LVKEGANINA QSQNGFTPLY MAAQENHIDV VKYLLENGAN QSTATEDGFT
PLAVALQQGH NQAVAILLEN DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKSG
FTPLHIAAHY GNVNVATLLL NRGAAVDFTA RNGITPLHVA SKRGNTNMVK LLLDRGGQID
AKTRDGLTPL HCAARSGHDQ VAELLLERGA PLLARTKNGL SPLHMAAQGD HVECVKHLLQ
HKAPVDDVTL DYLTALHVAA HCGHYRVTKL LLDKRANPNA RALNGFTPLH IACKKNRIKV
MELLVKYGAS IQAITESGLT PIHVAAFMGH LNIVLLLLQN GASPDVTNIR GETALHMAAR
AGQVEVVRCL LRNGALVDAR AREEQTPLHI ASRLGKTEIV QLLLQHMAHP DAATTNGYTP
LHISAREGQV DVASVLLEAG AAHSLATKKG FTPLHVAAKY GSLDVAKLLL QRRAAADSAG
KNGLTPLHVA AHYDNQKVAL LLLEKGASPH ATAKNGYTPL HIAAKKNQMQ IASTLLNYGA
ETNIVTKQGV TPLHLASQEG HTDMVTLLLD KGANIHMSTK SGLTSLHLAA QEDKVNVADI
LTKHGADQDA HTKLGYTPLI VACHYGNVKM VNFLLKQGAN VNAKTKNGYT PLHQAAQQGH
THIINVLLQH GAKPNACTAN GNTALAIAKR LGYISVVDTL KVVTEEVTTT TTTITEKHKL
NVPETMTEVL DVSDEEGDDT MTGDGGEYLR PEDLKELGDD SLPSSQFLDG MNYLRYSLEG
ARSDSTMPSL RSFSSDRSHT LSHASYLRDS AMIDDTMVIP SHQVSTLAKE AERNSYRLSW
GTENLDNVAL SSSPIHSGFL VSFMVDARGG AMRGCRHNGL RIIIPPRKCT APTRVTCRLV
KRHRLATMPP MVEGEGLASR LIEVGPSGAQ FLGPVIVEIP HFAALRGKER ELVVLRSENG
DSWKEHYCEY TEDELNEILN GMDEVLDSPE DLEKKRICRI ITRDFPQYFA VVSRIKQDSN
LIGPEGGVLS STVAPQVQAV FPEGALTKRI RVGLQAQPMH SELVKKILGN KATFSPIVTL
EPRRRKFHKP ITMTIPVPKA SSDVMLNGFG GDAPTLRLLC SITGGTTPAQ WEDITGTTPL
TFVNECVSFT TNVSARFWLI DCRQIQESVT FASQVYREII CVPYMAKFVV FAKSHDPIEA
RLRCFCMTDD KVDKTLEQQE NFAEVARSRD VEVLEGKPIY VDCFGNLVPL TKSGQHHIFS
FFAFKENRLP LFVKVRDTTQ EPCGRLSFMK EPKSTRGLVH QAICNLNITL PIYTKESESD
QEQEEEIDMT SEKNDETEST ETSVLKSHLV NEVPVLASPD LLSEVSEMKQ DLIKMTAILT
TDVSDRAGSI KVKELVKAAE EEPGEPFEIV ERVKEDLEKV NEILRSGTCT RDEGSMPRSQ
LERELVEEEW VIVSDEEIEE AKLKAPLEVT EYPCVEVRLD KESNVKVEKD SAGLVNYLTE
DLRSYVSPHE KHLQPAQERA GEKREAPPIG RSSENEGKDA PPETQSAQKQ QKPSLGIKKP
VRRKLKEKQK QKEESVQGSA EKSELKKCSS EESLEEDAGL APEPLPTVKA TSPLIEETPI
GSIKDKVKAL QKRVEDEQKG RSKLPVRVKG KEDVPKKITH RTHPAASPSL KSERHVPVSP
SSKTERHSSL SSSTKTERHP PLSPSSKTEK HSPVSPSAKI ERHSPVSSSS KTEKHSPVSP
STKTERHSPV SSTKTERHPP VSPSGKMDKR PPVSPSGRVE KHAPVSPGRT EKRLPVSPAG
RLEKHPPVST SGKTDKHLPV SPSGKIEKQP PVSPTSKTER IEETMSVREL MKAFQSGQDP
SKHKTGLFEH KSAKQKQPQE KGKARVEKEK GANQRETQKT ESQTIKRSQR FVVTGVSESK
RAVRASSVGF KREDVVVEKE KALSHKTPEP VQSAPEEESH KENEVPKEKL ADEQGDMDLQ
ISPDRKTSTD FSDVIKQELE DNDKYQQFRM SEKTEEVQLH LDQVLTSPFN TTFPLDYMKD
EFLPALSLQN GALDGSPESL KPEGVPGSPC GSLMEGTPQI SSEESYKHEG LAETPETSPE
SLSFSPKKSE EQVGEVSETT KVETPAAVHS EKEHPSVKDI TDGFEEQGAV VTKGTEPSAE
HLLKEATLDP SSEDTCLKRE DDSLGSCSML LAKETPKGLT EEASSDEAQP TDTGSTHKTQ
TDTEAQKSTT TEPSDETEAS PRPNASVKTG TGTESKPQGV ARSPQGLELA LPSRDSEVLS
PGADESFAVS HRDSLEASPV LEDNSSHKTP DSLEPSPLKE SPCRDSLESS PVEPKMKAGV
LPSHFPLPAA VAKTELLTEV ASVRSRLLRD PDGSAEDDSL EQTSLVESSG KSPLSPDTPS
SEEISYEVTP KATDASTPKP AVIHECAEED DLENGEKKRF TPEEEMFKMV TKIKTFDELE
QEAKQKRDYK KEPKQEESSS SSDPDADCTA DVDESKHMES VEDESDVPVV VTSESRKASS
SSESEPELAQ LKKGADSGLL PEPVIRVQPP SPLPSSIDSN SSPEEVQFQP IVSKQYTFKM
NEDTQEESGK SEEEKDHESC VPEESPTISP DGQDMFDDDL DRDAAQTEVC DGHGCETGSP
GSSVTPISSG LYSSPREDTN EQQVIHEESL PLQDTDEKIT EGEELDVSRV ESLQGDCPSE
SPSSLSSLPH IPISEGQELD EAVFSPPSTT EMEDTKTDQA FESLPEDSST QDSLTATQTD
KLSVDVPASD PADTDEIYDP QVISPYENVP SQSFFSSEES KTQTETRHTS FQSSEVHSVT
TTSSVEDVVV TSSSNRTVSS QESNFEDQNM EKESKQESIL WERQSDGAPS SLEPSVPNTS
AVVGEQISKV IITKTDVDSD SWSEIREDDE AFEARVKEEE QKIFGLMVDR QSQGTTPDTT
PARTPTEEGT PTSEQNPFLF QEGKLFEMTR SGAIDMTKRS YADESFHFFQ IGQESREETV
SEEMKEGSPG AELPQQETSA ESLALLESKE AVSDEADLLP DDLSEEVEEI SASDAQLNSH
VGNSDSVEIS MEETPSAGAE DPPTMQMGDM SPKSSVKNTS CPDPPEPVVH VQLDFSTVTR
SVYSDRNDDS PDSSPEEQRS VIEIPTAPME NVPSTENKSK IPVRTIPMST PAPPSVEYEN
SLSEDFLPSL DEESKEDEIK PKSKIPVKAP VQRVEQQLLH LDSSLQKIVA PQGQDMTSRT
PESRSKSESD ASPLDSKTKC PVKTKSYTET ETESTEGDEE LELESEEGAT RPKIFTSRLP
VKSKSTTSSC KGAVSPTKES KEHFFDLYRN SIEFFEEISD EASKLVDRLT QSEREQELVS
DDESSSALEV SVIENLPPVE TEHSIPEDIF DTRPIWDESI ETLIERIPDE NGHDHAEDQQ
DEQERIEERL AYIADHLGFS WTELARELDF TEEQIHQIRI ENPNSLQDQS HALLKYWLER
DGKHATDTNL IECLTKINRM DIVHLMEAST EPLQERITHS YAEIEQTIAL DHSEGFSVLQ
EELNTAQHKQ KEEQAASKES ESCDHPPIVS EEDISVGYST FQDCIPKAEG DSSATELFPQ
THKEQVQQDF SGKTQGLPEE SSLECQQEYF VTTPGTEVSE TQKPTAESAS PSKTPEEIRT
PPEEERPYLQ TPTSSEHGDS PIIQEPEEPP ERGEESPRKT SLVIVESADD QSQILERPDE
DAAFHKELTE ELGELEASSD EEAMVTTRVV RRRVIIQGDD MPDIPPETVT EEEYIDEHGH
TVVKKVTRKI IRRYVSSDGT EKEEVTMQGT AQGPISIEEG DVYSKVMKRI VLKSDIEQSE
VTLSEPSILS STSQFQAEPV EGRRVSKVVK TTVVHGERME KHLGDSSLAT DLPSAKDDFE
EDNNE
//
