ID A0A3Q7U9L2_VULVU Unreviewed; 607 AA.
AC A0A3Q7U9L2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Zinc finger CCHC domain-containing protein 8 {ECO:0000256|ARBA:ARBA00022379};
DE AltName: Full=TRAMP-like complex RNA-binding factor ZCCHC8 {ECO:0000256|ARBA:ARBA00032546};
GN Name=ZCCHC8 {ECO:0000313|RefSeq:XP_025874596.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025874596.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025874596.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025874596.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025874596.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the ZCCHC8 family.
CC {ECO:0000256|ARBA:ARBA00007497}.
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DR RefSeq; XP_025874596.1; XM_026018811.1.
DR AlphaFoldDB; A0A3Q7U9L2; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR006568; PSP_pro-rich.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR13316:SF0; ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR13316; ZINC FINGER, CCHC DOMAIN CONTAINING 8; 1.
DR Pfam; PF04046; PSP; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00581; PSP; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 130..144
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 310..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..397
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 67227 MW; 778ED6209DF4A448 CRC64;
MNNVISKQYH QEIEEFVSNL VKRFEEQQKN DVEKTSFNLL PQPSSVMLEE DHKVEESCAI
ENNKEAFSVV GSVLYFTNFC LDKLGQPLLN ENPQLTEGWE IPKYQQVFSH IVSLEGQEIQ
VKAKRPKPHC FNCGSEEHQM KDCPMPRNAA RISEKRKEYM DACSETNSQN FQQRYHAEEV
EERFGRFKPG VISEELQDAL GLTDKSLPPF IYRMRQLGYP PGWLKEAELE NSGLALYDGK
DGADGEAEAG ETQQNKSVTY DLSKLVNYPG FNISTPRGIS DEWRMFGSIP MQACQQKDVF
ANYLTSNFQA PSLRSGSKRS SSQSSPSSPK KQKKESSSGA SPADMELDSD AEVPHSSPGG
AFQFQPPLPP GTPPPLPQGT PPPIFTPPLP KGTPPLTPSD SPQTRAASAA MDEDSLTLEE
LEEQQRRIWA ALEQAESVNS DSDIPVDTPL TGNSLVSSPC PHELDLPVPE GKPSEKQRPE
EPEGPDVCTK KLEVEHSLSP DSEPPLLCQE EEEESVQIDS KDALDNGNGV SNCDVSNGGG
QKLLHVDTSP STATKIHSPV PDMSKFATGI TPFEFENMAE STGMYLRIRN LLKNSPRNQQ
KNKKASE
//
