ID A0A3Q7UA10_VULVU Unreviewed; 473 AA.
AC A0A3Q7UA10;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=THUMP domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_025874766.1};
GN Name=THUMPD2 {ECO:0000313|RefSeq:XP_025874766.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025874766.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025874766.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025874766.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025874766.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361}.
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DR RefSeq; XP_025874766.1; XM_026018981.1.
DR AlphaFoldDB; A0A3Q7UA10; -.
DR STRING; 9627.ENSVVUP00000025394; -.
DR Ensembl; ENSVVUT00000033630; ENSVVUP00000025394; ENSVVUG00000018628.
DR KEGG; vvp:112935310; -.
DR OMA; LLPVECY; -.
DR OrthoDB; 5406466at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 120..235
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 473 AA; 53087 MW; FD4747C43EEE34E7 CRC64;
MREVRARLAA TQVEYISGKV FFTTCSDLNM LKKLKSAERL FLLIKKKFPL NVPSVNKGKI
FNEMQNLVND DPESWLNAIS IWKNLLELDT KKGKLSQRDA NPLKRKVEEN DIINPKKLKT
EQMQELQESR ECQLEKEIEE ETPEQDFLTK REKSQEAFQN DVVKAGDTQN QKDLTFRVSC
RCSGAIAKTF TAQEVGRVIG IAVMKQFGWK ADLRNPNLEI FIHLNDVYSV VGIPVFRVPL
ASRAYIKTAG LRSTIAWAMA SLAEIKAGAF VLDPMCGLGT ILLEAAKEWP DVYYVGADAS
DSQLLGACDN LKAAGLKDKI ELLKVSVIEL PLPSESVDII ISDIPFGKKF KLRKDIKSIL
QEMERVLHVG GTIVLLLSED HHRRLQNCEQ SSIPLNSDLR MTTDELGIEK CLNPGEKTSI
PETVSSSSEA SNQEGLDKML PFGSLVPVEC YKVSLGRTDA FIYKYRKSHS FGL
//
